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European Spine Journal

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Open Access 01-02-2019 | Original Article

Intrasubject repeatability of in vivo intervertebral motion parameters using quantitative fluoroscopy

Authors: Alexander Breen, Rebecca Hemming, Fiona Mellor, Alan Breen

Published in: European Spine Journal | Issue 2/2019

Abstract

Purpose

In vivo quantification of intervertebral motion through imaging has progressed to a point where biomarkers for low back pain are emerging. This makes possible deeper study of the condition’s biometrics. However, the measurement of change over time involves error. The purpose of this prospective investigation is to determine the intrasubject repeatability of six in vivo intervertebral motion parameters using quantitative fluoroscopy.

Methods

Intrasubject reliability (ICC) and minimal detectable change (MDC) of baseline to 6-week follow-up measurements were calculated for six lumbar spine intervertebral motion parameters in 109 healthy volunteers. A standardised quantitative fluoroscopy (QF) protocol was used to provide measurements in the coronal and sagittal planes using both passive recumbent and active weight-bearing motion. Parameters were: intervertebral range of motion (IV-RoM), laxity, motion sharing inequality (MSI), motion sharing variability (MSV), flexion translation and anterior disc height change during flexion.

Results

The best overall intrasubject reliability (ICC) and agreement (MDC) were for disc height (ICC 0.89, MDC 43%) and IV-RoM (ICC 0.96, MDC 60%), and the worst for MSV (ICC 0.04, MDC 408%). Laxity, MSI and translation had acceptable reliability (most ICCs > 0.60), but not agreement (MDC > 85%).

Conclusion

Disc height and IV-RoM measurement using QF could be considered for randomised trials, while laxity, MSI and translation could be considered for moderators, correlates or mediators of patient-reported outcomes. MSV had both poor reliability and agreement over 6 weeks.

Graphical abstract

These slides can be retrieved under Electronic Supplementary Material.

Available only for authorised users

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Title: Intrasubject repeatability of in vivo intervertebral motion parameters using quantitative fluoroscopy
Authors: Alexander Breen
Rebecca Hemming
Fiona Mellor
Alan Breen
Publication date: 01-02-2019
Publisher: Springer Berlin Heidelberg
Published in: European Spine Journal / Issue 2/2019
Print ISSN: 0940-6719
Electronic ISSN: 1432-0932
DOI: https://doi.org/10.1007/s00586-018-5849-9

At a glance: The STEP trials

Springer Medicine

Intrasubject repeatability of in vivo intervertebral motion parameters using quantitative fluoroscopy

Abstract

Purpose

Methods

Results

Conclusion

Graphical abstract

At a glance: The STEP trials

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusion

Graphical abstract

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