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Published in: Supportive Care in Cancer 2/2010

01-02-2010 | Review Article

Intraspinal techniques for pain management in cancer patients: a systematic review

Authors: Jeff Myers, Vincent Chan, Virginia Jarvis, Cindy Walker-Dilks

Published in: Supportive Care in Cancer | Issue 2/2010

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Abstract

Purpose

This systematic review outlines current evidence regarding the effectiveness of intraspinal techniques for cancer pain and addresses practical implementation issues.

Methods

A search of electronic databases identified systematic reviews and randomized controlled trials (RCTs) evaluating the effectiveness of intraspinal techniques in the setting of cancer pain. An environmental scan was completed via the internet to identify practice guidelines and resource documents addressing organizational and implementation issues in the delivery of intraspinal analgesia. Elements reviewed included patient selection, contraindications, monitoring, aftercare, follow-up, hospital discharge equipment, health personnel, patient education, and safety.

Main results

Three systematic reviews, three consensus conferences, and 12 RCTs met the inclusion criteria for evidence of effectiveness. No single systematic review or consensus conference included all relevant RCTs or specifically addressed the use of intraspinal techniques for cancer pain. Six RCTs compared intraspinal techniques alone or combined with other interventions alone or in combination, four compared different intraspinal medications, and two compared different intraspinal techniques. In general, the evidence supported the use of intraspinal techniques for cancer pain management. The two main indications consistently identified were intractable pain not controlled by other conventional medical routes and/or side effects from conventional pain management strategies preventing dose escalation. Reports indicate intraspinal analgesia is equally or more effective than conventional medical management and often associated with fewer side effects. Thirteen resource documents addressed issues surrounding the delivery of intraspinal analgesia and program implementation.

Conclusions

Intraspinal techniques monitored by an interprofessional health care team should be included as part of a comprehensive cancer pain management program.
Literature
2.
go back to reference World Health Organization (1986) Cancer Pain Relief. World Health Organization, Geneva World Health Organization (1986) Cancer Pain Relief. World Health Organization, Geneva
3.
go back to reference Grond S, Zech D, Schug SA, Lynch J, Lehmann KA (1991) Validation of World Health Organization guidelines for cancer pain relief during the last days and hours of life. J Pain Symptom Manage 6(7):411–422CrossRefPubMed Grond S, Zech D, Schug SA, Lynch J, Lehmann KA (1991) Validation of World Health Organization guidelines for cancer pain relief during the last days and hours of life. J Pain Symptom Manage 6(7):411–422CrossRefPubMed
4.
go back to reference World Health Organization (1996) Cancer pain relief and palliative care: report of a WHO Expert Committee, 3rd edn. World Health Organization, Geneva World Health Organization (1996) Cancer pain relief and palliative care: report of a WHO Expert Committee, 3rd edn. World Health Organization, Geneva
5.
go back to reference Walker SM, Goudas LC, Cousins MJ, Carr DB (2002) Combination spinal analgesic chemotherapy: a systematic review. Anesth Analg 95(3):674–715CrossRefPubMed Walker SM, Goudas LC, Cousins MJ, Carr DB (2002) Combination spinal analgesic chemotherapy: a systematic review. Anesth Analg 95(3):674–715CrossRefPubMed
6.
go back to reference Raffaeli W, Andruccioli J, Righetti D, Caminiti A, Balestri M (2006) Intraspinal therapy for the treatment of chronic pain: a review of the literature between 1990 and 2005 and suggested protocol for its rational and safe use. Neuromodulation 9(4):290–308CrossRef Raffaeli W, Andruccioli J, Righetti D, Caminiti A, Balestri M (2006) Intraspinal therapy for the treatment of chronic pain: a review of the literature between 1990 and 2005 and suggested protocol for its rational and safe use. Neuromodulation 9(4):290–308CrossRef
7.
go back to reference Carr D, Goudas L, Lawrence D, Pirl W, Lau J, DeVine D, Kupelnick B, Miller K (2002) Management of cancer symptoms: pain, depression, and fatigue. Evid Rep Technol Assess (Summ) 61:1–5 Carr D, Goudas L, Lawrence D, Pirl W, Lau J, DeVine D, Kupelnick B, Miller K (2002) Management of cancer symptoms: pain, depression, and fatigue. Evid Rep Technol Assess (Summ) 61:1–5
8.
go back to reference Hassenbusch SJ, Portenoy RK, Cousins M, Buchser E, Deer TR, Du Pen SL et al (2004) Polyanalgesic Consensus Conference 2003: an update on the management of pain by intraspinal drug delivery–report of an expert panel. J Pain Symptom Manage 27(6):540–563CrossRefPubMed Hassenbusch SJ, Portenoy RK, Cousins M, Buchser E, Deer TR, Du Pen SL et al (2004) Polyanalgesic Consensus Conference 2003: an update on the management of pain by intraspinal drug delivery–report of an expert panel. J Pain Symptom Manage 27(6):540–563CrossRefPubMed
9.
go back to reference Stearns L, Boortz-Marx R, Du Pen S, Friehs G, Gordon M, Halyard M et al (2005) Intrathecal drug delivery for the management of cancer pain: a multidisciplinary consensus of best clinical practices. J Support Oncol 3(6):399–408PubMed Stearns L, Boortz-Marx R, Du Pen S, Friehs G, Gordon M, Halyard M et al (2005) Intrathecal drug delivery for the management of cancer pain: a multidisciplinary consensus of best clinical practices. J Support Oncol 3(6):399–408PubMed
10.
go back to reference Bennett G, Burchiel K, Buchser E, Classen A, Deer T, Du Pen S et al (2000) Clinical guidelines for intraspinal infusion: report of an expert panel. PolyAnalgesic Consensus Conference 2000. J Pain Symptom Manage 20(2):S37–S43CrossRefPubMed Bennett G, Burchiel K, Buchser E, Classen A, Deer T, Du Pen S et al (2000) Clinical guidelines for intraspinal infusion: report of an expert panel. PolyAnalgesic Consensus Conference 2000. J Pain Symptom Manage 20(2):S37–S43CrossRefPubMed
11.
go back to reference Vainio A, Tigerstedt I (1988) Opioid treatment for radiating cancer pain: oral administration vs. epidural techniques. Acta Anaesthesiol Scand 32(3):179–185CrossRefPubMed Vainio A, Tigerstedt I (1988) Opioid treatment for radiating cancer pain: oral administration vs. epidural techniques. Acta Anaesthesiol Scand 32(3):179–185CrossRefPubMed
12.
go back to reference Smith TJ, Staats PS, Deer T, Stearns LJ, Rauck RL, Boortz-Marx RL et al (2002) Randomized clinical trial of an implantable drug delivery system compared with comprehensive medical management for refractory cancer pain: impact on pain, drug-related toxicity, and survival. J Clin Oncol 20(19):4040–4049CrossRefPubMed Smith TJ, Staats PS, Deer T, Stearns LJ, Rauck RL, Boortz-Marx RL et al (2002) Randomized clinical trial of an implantable drug delivery system compared with comprehensive medical management for refractory cancer pain: impact on pain, drug-related toxicity, and survival. J Clin Oncol 20(19):4040–4049CrossRefPubMed
13.
go back to reference Kalso E, Heiskanen T, Rantio M, Rosenberg PH, Vainio A (1996) Epidural and subcutaneous morphine in the management of cancer pain: a double-blind cross-over study. Pain 67(2–3):443–449CrossRefPubMed Kalso E, Heiskanen T, Rantio M, Rosenberg PH, Vainio A (1996) Epidural and subcutaneous morphine in the management of cancer pain: a double-blind cross-over study. Pain 67(2–3):443–449CrossRefPubMed
14.
go back to reference Staats PS, Yearwood T, Charapata SG, Presley RW, Wallace MS, Byas-Smith M et al (2004) Intrathecal ziconotide in the treatment of refractory pain in patients with cancer or AIDS: a randomized controlled trial. JAMA 291(1):63–70CrossRefPubMed Staats PS, Yearwood T, Charapata SG, Presley RW, Wallace MS, Byas-Smith M et al (2004) Intrathecal ziconotide in the treatment of refractory pain in patients with cancer or AIDS: a randomized controlled trial. JAMA 291(1):63–70CrossRefPubMed
15.
go back to reference Eisenach JC, DuPen S, Dubois M, Miguel R, Allin D (1995) Epidural clonidine analgesia for intractable cancer pain. The Epidural Clonidine Study Group. Pain 61(3):391–399CrossRefPubMed Eisenach JC, DuPen S, Dubois M, Miguel R, Allin D (1995) Epidural clonidine analgesia for intractable cancer pain. The Epidural Clonidine Study Group. Pain 61(3):391–399CrossRefPubMed
16.
go back to reference Pasqualucci V, Tantucci C, Paoletti F, Dottorini ML, Bifarini G, Belfiori R et al (1987) Buprenorphine vs. morphine via the epidural route: a controlled comparative clinical study of respiratory effects and analgesic activity. Pain 29(3):273–286CrossRefPubMed Pasqualucci V, Tantucci C, Paoletti F, Dottorini ML, Bifarini G, Belfiori R et al (1987) Buprenorphine vs. morphine via the epidural route: a controlled comparative clinical study of respiratory effects and analgesic activity. Pain 29(3):273–286CrossRefPubMed
17.
go back to reference Dahm P, Lundborg C, Janson M, Olegård C, Nitescu P (2000) Comparison of 0.5% intrathecal bupivacaine with 0.5% intrathecal ropivacaine in the treatment of refractory cancer and noncancer pain conditions: results from a prospective, crossover, double-blind, randomized study. Reg Anesth Pain Med 25(5):480–487PubMed Dahm P, Lundborg C, Janson M, Olegård C, Nitescu P (2000) Comparison of 0.5% intrathecal bupivacaine with 0.5% intrathecal ropivacaine in the treatment of refractory cancer and noncancer pain conditions: results from a prospective, crossover, double-blind, randomized study. Reg Anesth Pain Med 25(5):480–487PubMed
18.
go back to reference van Dongen RT, Crul BJ, van Egmond J (1999) Intrathecal coadministration of bupivacaine diminishes morphine dose progression during long-term intrathecal infusion in cancer patients. Clin J Pain 15(3):166–172CrossRefPubMed van Dongen RT, Crul BJ, van Egmond J (1999) Intrathecal coadministration of bupivacaine diminishes morphine dose progression during long-term intrathecal infusion in cancer patients. Clin J Pain 15(3):166–172CrossRefPubMed
19.
go back to reference Lauretti GR, Gomes JM, Reis MP, Pereira NL (1999) Low doses of epidural ketamine or neostigmine, but not midazolam, improve morphine analgesia in epidural terminal cancer pain therapy. J Clin Anesth 11(8):663–668CrossRefPubMed Lauretti GR, Gomes JM, Reis MP, Pereira NL (1999) Low doses of epidural ketamine or neostigmine, but not midazolam, improve morphine analgesia in epidural terminal cancer pain therapy. J Clin Anesth 11(8):663–668CrossRefPubMed
20.
go back to reference Yang CY, Wong CS, Chang JY, Ho ST (1996) Intrathecal ketamine reduces morphine requirements in patients with terminal cancer pain. Can J Anaesth 43(4):379–383CrossRefPubMed Yang CY, Wong CS, Chang JY, Ho ST (1996) Intrathecal ketamine reduces morphine requirements in patients with terminal cancer pain. Can J Anaesth 43(4):379–383CrossRefPubMed
21.
go back to reference Gourlay GK, Plummer JL, Cherry DA, Onley MM, Parish KA, Wood MM et al (1991) Comparison of intermittent bolus with continuous infusion of epidural morphine in the treatment of severe cancer pain. Pain 47(2):135–140CrossRefPubMed Gourlay GK, Plummer JL, Cherry DA, Onley MM, Parish KA, Wood MM et al (1991) Comparison of intermittent bolus with continuous infusion of epidural morphine in the treatment of severe cancer pain. Pain 47(2):135–140CrossRefPubMed
22.
go back to reference Georgiou L, Louizos A, Sklavou C, Manolopoulos L, Yiotakis I, Adamopoulos G (2000) Cervical versus thoracic epidural morphine for the treatment of head and neck cancer pain. Ann Otol Rhinol Laryngol 109(7):676–678PubMed Georgiou L, Louizos A, Sklavou C, Manolopoulos L, Yiotakis I, Adamopoulos G (2000) Cervical versus thoracic epidural morphine for the treatment of head and neck cancer pain. Ann Otol Rhinol Laryngol 109(7):676–678PubMed
23.
go back to reference Oncology Nursing Society (2004) Access device guidelines: recommendations for nursing practice and education. 2nd ed. Pittsburgh: Oncology Nursing Society (ONS) Oncology Nursing Society (2004) Access device guidelines: recommendations for nursing practice and education. 2nd ed. Pittsburgh: Oncology Nursing Society (ONS)
24.
go back to reference British Pain Society (2006) Intrathecal drug delivery for the management of pain and spasticity in adults; recommendations for best clinical practice. British Pain Society, London British Pain Society (2006) Intrathecal drug delivery for the management of pain and spasticity in adults; recommendations for best clinical practice. British Pain Society, London
25.
go back to reference Broadfield L, Banerjee S, Jewers H, Pollett AJ, Simpson J (2005) Guidelines for the management of cancer-related pain in adults. Supportive Care Cancer Site Team. Cancer Care Nova Scotia Broadfield L, Banerjee S, Jewers H, Pollett AJ, Simpson J (2005) Guidelines for the management of cancer-related pain in adults. Supportive Care Cancer Site Team. Cancer Care Nova Scotia
26.
go back to reference Scottish Intercollegiate Guidelines Network (SIGN) (2000) Control of pain in patients with cancer: a national clinical guideline. Edinburgh: Scottish Intercollegiate Guidelines Network Scottish Intercollegiate Guidelines Network (SIGN) (2000) Control of pain in patients with cancer: a national clinical guideline. Edinburgh: Scottish Intercollegiate Guidelines Network
27.
go back to reference Clinical practice guidelines: cancer pain. Singapore: Ministry of Health; 2003 Clinical practice guidelines: cancer pain. Singapore: Ministry of Health; 2003
28.
go back to reference Miaskowski C, Cleary J, Burney R, Coyne P, Finley R, Foster R et al (2005) Guideline for the management of cancer pain in adults and children. APS Clinical Practice Guideline Series, 3rd edn. American Pain Society, Glenview, IL Miaskowski C, Cleary J, Burney R, Coyne P, Finley R, Foster R et al (2005) Guideline for the management of cancer pain in adults and children. APS Clinical Practice Guideline Series, 3rd edn. American Pain Society, Glenview, IL
29.
go back to reference NCCN Clinical Practice Guidelines in Oncology (2007) Adult cancer pain. National Comprehensive Cancer Network, Fort Washington, PA NCCN Clinical Practice Guidelines in Oncology (2007) Adult cancer pain. National Comprehensive Cancer Network, Fort Washington, PA
30.
go back to reference Practice guidelines for cancer pain management: a report by the American Society of Anesthesiologists Task Force on pain management, cancer pain section. Anesthesiology, 1996 May, 84:1243–1257 Practice guidelines for cancer pain management: a report by the American Society of Anesthesiologists Task Force on pain management, cancer pain section. Anesthesiology, 1996 May, 84:1243–1257
31.
go back to reference Palliative epidural analgesia (2004) Interdisciplinary education & resource manual. Calgary Health Region, Calgary Palliative epidural analgesia (2004) Interdisciplinary education & resource manual. Calgary Health Region, Calgary
32.
go back to reference Guidelines for the management of intraspinal catheters in the community in Cornwall. St Austell (UK): Cornwall Healthcare NHS Trust; 2001 Guidelines for the management of intraspinal catheters in the community in Cornwall. St Austell (UK): Cornwall Healthcare NHS Trust; 2001
33.
go back to reference Nursing policy, procedure, protocol manual. Pain (chronic and chronic malignant): epidural and intrathecal infusions. The Ottawa Hospital; 2007 Nursing policy, procedure, protocol manual. Pain (chronic and chronic malignant): epidural and intrathecal infusions. The Ottawa Hospital; 2007
34.
go back to reference The management of epidural drugs. St. Wilfrid’s Hospice, Eastbourne, UK; 2001 The management of epidural drugs. St. Wilfrid’s Hospice, Eastbourne, UK; 2001
35.
go back to reference Infusion Nurses Society (2006) Infusion nursing standards of practice. J Infus Nurs 29(1 Suppl):S1–S92 Infusion Nurses Society (2006) Infusion nursing standards of practice. J Infus Nurs 29(1 Suppl):S1–S92
37.
go back to reference Deer T, Krames ES, Hassenbusch SJ, Burton A, Caraway D, Dupen S et al (2007) Polyanalgesic Cnsensus conference 2007: recommendations for the management of pain by intrathecal (intraspinal) drug delivery: report of an interdisciplinary expert panel. Neuromodulation: Technology at the Neural Interface 10:300–328 Deer T, Krames ES, Hassenbusch SJ, Burton A, Caraway D, Dupen S et al (2007) Polyanalgesic Cnsensus conference 2007: recommendations for the management of pain by intrathecal (intraspinal) drug delivery: report of an interdisciplinary expert panel. Neuromodulation: Technology at the Neural Interface 10:300–328
38.
go back to reference Smith TJ, Coyne PJ (2005) Implantable drug delivery systems (IDDS) after failure of comprehensive medical management (CMM) can palliate symptoms in the most refractory cancer pain patients. J Palliat Med 8(4):736–742CrossRefPubMed Smith TJ, Coyne PJ (2005) Implantable drug delivery systems (IDDS) after failure of comprehensive medical management (CMM) can palliate symptoms in the most refractory cancer pain patients. J Palliat Med 8(4):736–742CrossRefPubMed
39.
go back to reference Smith TJ, Coyne PJ, Staats PS, Deer T, Stearns LJ, Rauck RL et al (2005) An implantable drug delivery system (IDDS) for refractory cancer pain provides sustained pain control, less drug-related toxicity, and possibly better survival compared with comprehensive medical management (CMM). Ann Oncol 16(5):825–833CrossRefPubMed Smith TJ, Coyne PJ, Staats PS, Deer T, Stearns LJ, Rauck RL et al (2005) An implantable drug delivery system (IDDS) for refractory cancer pain provides sustained pain control, less drug-related toxicity, and possibly better survival compared with comprehensive medical management (CMM). Ann Oncol 16(5):825–833CrossRefPubMed
40.
go back to reference Ellis DJ, Dissanayake S, McGuire D, Charapata SG, Staats PS, Wallace MS et al (2008) Continuous intrathecal infusion of ziconotide for treatment of chronic malignant and nonmalignant pain over 12 months: A prospective, open-label study. Neuromodulation 11(1):40–49 Ellis DJ, Dissanayake S, McGuire D, Charapata SG, Staats PS, Wallace MS et al (2008) Continuous intrathecal infusion of ziconotide for treatment of chronic malignant and nonmalignant pain over 12 months: A prospective, open-label study. Neuromodulation 11(1):40–49
41.
go back to reference Birnbach DJ, Meadows W, Stein DJ, Murray O, Thys DM, Sordillo EM (2003) Comparison of povidone iodine and DuraPrep, an iodophor-in-isopropyl alcohol solution, for skin disinfection prior to epidural catheter insertion in parturients. Anesthesiology 98(1):164–169CrossRefPubMed Birnbach DJ, Meadows W, Stein DJ, Murray O, Thys DM, Sordillo EM (2003) Comparison of povidone iodine and DuraPrep, an iodophor-in-isopropyl alcohol solution, for skin disinfection prior to epidural catheter insertion in parturients. Anesthesiology 98(1):164–169CrossRefPubMed
42.
go back to reference Sato S, Sakuragi T, Dan K (1996) Human skin flora as a potential source of epidural abscess. Anesthesiology 85(6):1276–1282CrossRefPubMed Sato S, Sakuragi T, Dan K (1996) Human skin flora as a potential source of epidural abscess. Anesthesiology 85(6):1276–1282CrossRefPubMed
43.
go back to reference Kasuda H, Fukuda H, Togashi H, Hotta K, Hirai Y, Hayashi M (2002) Skin disinfection before epidural catheterization: comparative study of povidone-iodine versus chlorhexidine ethanol. Dermatology 204(Suppl 1):42–46CrossRefPubMed Kasuda H, Fukuda H, Togashi H, Hotta K, Hirai Y, Hayashi M (2002) Skin disinfection before epidural catheterization: comparative study of povidone-iodine versus chlorhexidine ethanol. Dermatology 204(Suppl 1):42–46CrossRefPubMed
44.
go back to reference Parienti JJ, du Cheyron D, Ramakers M, Malbruny B, Leclercq R, Le Coutour X et al (2004) Alcoholic povidone-iodine to prevent central venous catheter colonization: a randomized unit-crossover study. Crit Care Med 32(3):708–713CrossRefPubMed Parienti JJ, du Cheyron D, Ramakers M, Malbruny B, Leclercq R, Le Coutour X et al (2004) Alcoholic povidone-iodine to prevent central venous catheter colonization: a randomized unit-crossover study. Crit Care Med 32(3):708–713CrossRefPubMed
45.
go back to reference Videira RL, Ruiz-Neto PP, Brandao Neto M (2002) Post spinal meningitis and asepsis. Acta Anaesthesiol Scand 46(6):639–646CrossRefPubMed Videira RL, Ruiz-Neto PP, Brandao Neto M (2002) Post spinal meningitis and asepsis. Acta Anaesthesiol Scand 46(6):639–646CrossRefPubMed
Metadata
Title
Intraspinal techniques for pain management in cancer patients: a systematic review
Authors
Jeff Myers
Vincent Chan
Virginia Jarvis
Cindy Walker-Dilks
Publication date
01-02-2010
Publisher
Springer-Verlag
Published in
Supportive Care in Cancer / Issue 2/2010
Print ISSN: 0941-4355
Electronic ISSN: 1433-7339
DOI
https://doi.org/10.1007/s00520-009-0784-2

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