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Journal of Hematopathology
Published in: Journal of Hematopathology 3/2013

01-09-2013 | Case Report

Intraosseous hibernoma or unusual location of brown fat?

Authors: David T. Lynch, Raetasha S. Dabney, Jared M. Andrews

Published in: Journal of Hematopathology | Issue 3/2013

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Abstract

The hibernoma is a rare benign tumor of brown fat. It is most commonly found subcutaneously in the thigh, shoulder, and back of middle-aged adults. Intraosseous hibernomas and brown fat are rarely reported. There are currently two reported cases in the literature, one of which occurred in the setting of essential thrombocythemia (ET). We report an intraosseous brown fat infiltrate found incidentally in a bone marrow biopsy of a 77-year-old female with ET.
Literature
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Lichtenbelt W, Vanhommerig J, Smulders N et al (2009) Cold-activated brown adipose tissue in healthy men. N Engl J Med 360(15):1500–1508CrossRef
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Furlong M, Fanburg-Smith J, Miettinen M (2001) The morphologic spectrum of hibernoma. Am J Surg Pathol 25(6):809–814PubMedCrossRef
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Gaffney E, Hargreaves H, Semple E, Vellios F (1982) Hibernoma: distinctive light and electron microscopic features and relationship to brown adipose tissue. Hum Pathol 14(8):677–687CrossRef
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Mertens F, Rydholm A, Brosjo O, Willen H, Mitelman F, Mandahl N (1994) Hibernomas are characterized by rearrangements of chromosome bands 11q13-21. Int J Cancer 58:503–505PubMedCrossRef
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Mrozek K, Karakousis C, Bloomfield C (1994) Band 11q13 is nonrandomly rearranged in hibernomas. Gene Chromosome Cancer 9:145–147CrossRef
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Kumar R, Deaver M, Czerniak B, Madewell J (2011) Intraosseous hibernoma. Skeletal Radiol 40:641–645PubMedCrossRef
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Thorns C, Schardt C, Katenkamp D, Kahler C, Merz H, Feller A (2007) Hibernoma-like brown fat in the bone marrow: report of a unique case. Virchows Arch 452(3):343–345CrossRef
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Rosso R, Lucioni M (2006) Normal and neoplastic cells of brown adipose tissue express the adhesion molecule CD31. Arch Pathol Lab Med 130:480–482PubMed
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Lele S, Chundru S, Chaljub G, Adegboyega P, Haque A (2002) Hibernoma: a report of 2 unusual cases with a review of the literature. Arch Pathol Lab Med 126:975–978PubMed
Metadata
Title
Intraosseous hibernoma or unusual location of brown fat?
Authors
David T. Lynch
Raetasha S. Dabney
Jared M. Andrews
Publication date
01-09-2013
Publisher
Springer Berlin Heidelberg
Published in
Journal of Hematopathology / Issue 3/2013
Print ISSN: 1868-9256
Electronic ISSN: 1865-5785
DOI
https://doi.org/10.1007/s12308-012-0165-5

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