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Open Access 01-12-2011 | Research

Intraoperative radiation therapy for advanced cervical metastasis: a single institution experience

Authors: Youssef H Zeidan, Alex Yeh, Daniel Weed, Colin Terry, Stephen Freeman, Edward Krowiak, Robert Borrowdale, Tod Huntley

Published in: Radiation Oncology | Issue 1/2011

Abstract

Background

The purpose of this study is to review our experience with the use of IORT for patients with advanced cervical metastasis.

Methods

Between August 1982 and July 2007, 231 patients underwent neck dissections as part of initial therapy or as salvage treatment for advanced cervical node metastases resulting from head and neck malignancies. IORT was administered as a single fraction to a dose of 15 Gy or 20 Gy in most pts. The majority was treated with 5 MeV electrons (112 pts, 50.5%).

Results

1, 3, and 5 years overall survival (OS) after surgery + IORT was 58%, 34%, and 26%, respectively. Recurrence-free survival (RFS) at 1, 3, and 5 years was 66%, 55%, and 49%, respectively. Disease recurrence was documented in 83 (42.8%) pts. The majority of recurrences were regional (38 pts), as compared to local recurrence in 20 pts and distant failures in 25 pts. There were no perioperative fatalities.

Conclusions

IORT results in effective local disease control at acceptable levels of toxicity. Our results support the initiation of a phase III trial comparing outcomes for patients with cervical metastasis treated with or without IORT.

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Title: Intraoperative radiation therapy for advanced cervical metastasis: a single institution experience
Authors: Youssef H Zeidan
Alex Yeh
Daniel Weed
Colin Terry
Stephen Freeman
Edward Krowiak
Robert Borrowdale
Tod Huntley
Publication date: 01-12-2011
Publisher: BioMed Central
Published in: Radiation Oncology / Issue 1/2011
Electronic ISSN: 1748-717X
DOI: https://doi.org/10.1186/1748-717X-6-72

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Intraoperative radiation therapy for advanced cervical metastasis: a single institution experience

Abstract

Background

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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