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Published in:

01-08-2004 | Original Paper

Intraoperative dissemination of tumour cells in patients with Ewing tumours detected by RT-PCR

Authors: J. G. Grohs, A. Zoubek, D. Jugovic, H. Kovar, R. Windhager

Published in: International Orthopaedics | Issue 4/2004

Abstract

Using reverse transcriptase polymerase chain reaction (RT-PCR) we evaluated the occurrence of tumour-cell ribonucleic acid (RNA) in the blood during surgery in patients with Ewing tumours. The patients received irradiation and chemotherapy according to the protocol of the European Intergroup Cooperative Ewing Sarcoma Study (EICESS) 92. Blood samples were taken from 15 patients. Intra-operative dissemination was found during 2/8 resections but showed no relation to patient survival. At second-look biopsy, detection of tumour-cell RNA was associated with relapse and metastases in 3/4 patients. The results suggest that pre-operative treatment did not completely prevent dissemination of tumour cells during surgery of Ewing tumours.

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Title: Intraoperative dissemination of tumour cells in patients with Ewing tumours detected by RT-PCR
Authors: J. G. Grohs
A. Zoubek
D. Jugovic
H. Kovar
R. Windhager
Publication date: 01-08-2004
Publisher: Springer-Verlag
Published in: International Orthopaedics / Issue 4/2004
Print ISSN: 0341-2695
Electronic ISSN: 1432-5195
DOI: https://doi.org/10.1007/s00264-004-0551-4

2024 ASCO Annual Meeting

Springer Medicine

Intraoperative dissemination of tumour cells in patients with Ewing tumours detected by RT-PCR

Abstract

2024 ASCO Annual Meeting

Springer Medicine

Abstract

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