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Neurocritical Care
Published in: Neurocritical Care 1/2010

01-02-2010 | Practical Pearl

Intracranial Hemorrhage Following Thrombolytic Use for Stroke Caused by Infective Endocarditis

Authors: Parita Bhuva, Sheng-Han Kuo, J. Claude Hemphill, George A. Lopez

Published in: Neurocritical Care | Issue 1/2010

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Abstract

Background and Purpose

Stroke is one of the most common neurological manifestations of infective endocarditis. The use of intravenous tissue plasminogen activator (t-PA) in the management of acute ischemic stroke is the accepted standard of practice.
Current guidelines for intravenous (IV) t-PA therapy in acute ischemic stroke do not exclude patients with infective endocarditis.

Summary of the Case

We present three patients who received IV t-PA for acute ischemic stroke in the setting of infective endocarditis and developed multifocal intracranial hemorrhage as a complication.

Conclusion

Infective endocarditis related strokes are associated with a higher risk of hemorrhagic complications and our experience suggests that IV t-PA use may potentiate that risk.
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Metadata
Title
Intracranial Hemorrhage Following Thrombolytic Use for Stroke Caused by Infective Endocarditis
Authors
Parita Bhuva
Sheng-Han Kuo
J. Claude Hemphill
George A. Lopez
Publication date
01-02-2010
Publisher
Humana Press Inc
Published in
Neurocritical Care / Issue 1/2010
Print ISSN: 1541-6933
Electronic ISSN: 1556-0961
DOI
https://doi.org/10.1007/s12028-009-9253-5

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