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Open Access 01-06-2008 | Original

Intracranial hemodynamics during intravenous infusion of glyceryl trinitrate

Authors: H. K. Iversen, S. Holm, L. Friberg, P. Tfelt-Hansen

Published in: The Journal of Headache and Pain | Issue 3/2008

Abstract

The mechanisms of glyceryl trinitrate (GTN)-induced headache are not fully elucidated. In this study we administered GTN 0.5 μg/kg/min i.v. for 20 min in six healthy volunteers. Before, during and 60 min after the infusion, we investigated regional cerebral blood flow (rCBF), cerebral blood volume (CBV), both estimated with SPECT, and blood flow velocity (BFV) in the middle cerebral artery (MCA), measured with transcranial Doppler. Headache was scored on a numerical verbal rating (0–10) scale. rCBF was unchanged, CBV was slightly increased (13%) during GTN infusion, whereas BFV decreased both during (20%) and 60 min (15%) after GTN. Headache was short-lived and maximal during infusion. This discrepancy of time-effect curves for the effect of GTN on headache and dilatation of MCA indicates that MCA is most likely not the primary source of pain in GTN-induced headache. The time-effect curves for the effect of GTN on headache and on dilation of MCA differed markedly. This indicates that MCA is most likely not the primary source of pain in GTN-induced headache.

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Title: Intracranial hemodynamics during intravenous infusion of glyceryl trinitrate
Authors: H. K. Iversen
S. Holm
L. Friberg
P. Tfelt-Hansen
Publication date: 01-06-2008
Publisher: Springer Milan
Published in: The Journal of Headache and Pain / Issue 3/2008
Print ISSN: 1129-2369
Electronic ISSN: 1129-2377
DOI: https://doi.org/10.1007/s10194-008-0034-x

At a glance: The STEP trials

Springer Medicine

Intracranial hemodynamics during intravenous infusion of glyceryl trinitrate

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

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