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European Journal of Pediatrics
Published in: European Journal of Pediatrics 4/2008

01-04-2008 | Short Report

Intracranial aneurysm associated with chronic mucocutaneous candidiasis

Authors: M. G. Marazzi, E. Bondi, A. Giannattasio, M. Strozzi, C. Savioli

Published in: European Journal of Pediatrics | Issue 4/2008

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Abstract

Chronic mucocutaneous candidiasis (CMC) is a syndrome characterised by immune deficiency, often presenting familial dominant inheritance and association with autoimmune endocrinopathies. We report on a patient with CMC who died at 5 years of age of a brain haemorrhage following the rupture of a basilar-artery aneurysm. Candida hyphae in the basilar artery were found at autopsy. A common immunologic abnormality in CMC is the failure of patient’s T-lymphocytes to produce cytokines, which are essential for expression of cell-mediated immunity to Candida. Therefore, long-term treatment is mandatory.
Literature
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Horsburgh CR Jr, Kirkpatrick CH (1983) Long term therapy of chronic mucocutaneous candidiasis with ketoconazole: experience with twenty-one patients. Am J Med 74:23–29PubMedCrossRef
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Loeys BL, Van Coster RN, Defreyne LR, Leroy JG (1999) Fungal intracranial aneurysm in a child with familial chronic mucocutaneous candidiasis. Eur J Pediatr 158:650–652PubMedCrossRef
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Metadata
Title
Intracranial aneurysm associated with chronic mucocutaneous candidiasis
Authors
M. G. Marazzi
E. Bondi
A. Giannattasio
M. Strozzi
C. Savioli
Publication date
01-04-2008
Publisher
Springer-Verlag
Published in
European Journal of Pediatrics / Issue 4/2008
Print ISSN: 0340-6199
Electronic ISSN: 1432-1076
DOI
https://doi.org/10.1007/s00431-007-0490-3

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