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Published in: Journal of Medical Case Reports 1/2012

Open Access 01-12-2012 | Case report

Intraarticular hemorrhage due to bevacizumab in a patient with metastatic colorectal cancer: a case report

Authors: Mukremin Uysal, Sema Sezgin Goksu, Hasan Senol Coskun, Burhan Savas, Mustafa Ozdogan, Hakan Bozcuk

Published in: Journal of Medical Case Reports | Issue 1/2012

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Abstract

Introduction

Bevacizumab is a monoclonal antibody against vascular endothelial growth factor. It is widely used in the treatment of metastatic colorectal cancer. It has some specific side effects including severe bleeding, wound healing problems, gastrointestinal perforation, proteinuria and hypertension.

Case presentation

We present the case of a 65-year old Asian man with synovial metastasis of the knee who experienced intraarticular hemorrhage after bevacizumab treatment. He presented with monoarthritis of the left knee.

Conclusion

Bevacizumab-related hemorrhage can cause serious morbidity and unusual sites of hemorrhage may be seen.
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Literature
1.
go back to reference Jemal A, Siegel R, Ward E, Hao Y, Xu J, Thun MJ: Cancer statistics. CA Cancer J Clin. 2009, 59: 225-249. 10.3322/caac.20006.CrossRefPubMed Jemal A, Siegel R, Ward E, Hao Y, Xu J, Thun MJ: Cancer statistics. CA Cancer J Clin. 2009, 59: 225-249. 10.3322/caac.20006.CrossRefPubMed
2.
go back to reference Wagner AD, Arnold D, Grothey AAG, Haerting J, Unverzagt S: Anti-angiogenic therapies for metastatic colorectal cancer. Cochrane Database Syst Rev. 2009, (3):CD005293. Wagner AD, Arnold D, Grothey AAG, Haerting J, Unverzagt S: Anti-angiogenic therapies for metastatic colorectal cancer. Cochrane Database Syst Rev. 2009, (3):CD005293.
3.
go back to reference Beckers C, Foidart J, Thiry A, Malaise MG: Synovial metastases from colonic cancer presenting as arthritis of the knee. Characterization by 18FDG PET scan. Rev Med Liege. 2002, 57: 467-474.PubMed Beckers C, Foidart J, Thiry A, Malaise MG: Synovial metastases from colonic cancer presenting as arthritis of the knee. Characterization by 18FDG PET scan. Rev Med Liege. 2002, 57: 467-474.PubMed
4.
go back to reference Griener B, Müller-Färber J: Patellar metastasis of colon carcinoma. A rarity in differential diagnosis of acute knee pain. Case report. Unfallchirurg. 2001, 104: 778-781. 10.1007/s001130170080.CrossRefPubMed Griener B, Müller-Färber J: Patellar metastasis of colon carcinoma. A rarity in differential diagnosis of acute knee pain. Case report. Unfallchirurg. 2001, 104: 778-781. 10.1007/s001130170080.CrossRefPubMed
5.
go back to reference Currall VA: Dixon John H: Synovial metastasis: an unusual cause of pain after total knee arthroplasty. J Arthroplasty. 2008, 23: 631-636. 10.1016/j.arth.2007.04.034.CrossRefPubMed Currall VA: Dixon John H: Synovial metastasis: an unusual cause of pain after total knee arthroplasty. J Arthroplasty. 2008, 23: 631-636. 10.1016/j.arth.2007.04.034.CrossRefPubMed
6.
go back to reference Devis P, Iwannik D, Aikens C: Metastatic adenocarcinoma presenting as monoarticular arthritis of the knee. AJR Am J Roentgenol. 2005, 184: S107-S109.CrossRefPubMed Devis P, Iwannik D, Aikens C: Metastatic adenocarcinoma presenting as monoarticular arthritis of the knee. AJR Am J Roentgenol. 2005, 184: S107-S109.CrossRefPubMed
7.
go back to reference Capovilla M, Durlach A, Fourati E, Beucher AB, Eschard JP, Dehoux E, Le Noach J, Cucherousset J: Chronic monoarthritis and previous history of cancer: think about synovial metastasis. Clin Rheumatol. 2007, 26: 60-63. 10.1007/s10067-006-0242-1.CrossRefPubMed Capovilla M, Durlach A, Fourati E, Beucher AB, Eschard JP, Dehoux E, Le Noach J, Cucherousset J: Chronic monoarthritis and previous history of cancer: think about synovial metastasis. Clin Rheumatol. 2007, 26: 60-63. 10.1007/s10067-006-0242-1.CrossRefPubMed
9.
go back to reference Saif MW, Mehra R: Incidence and management of bevacizumab-related toxicities in colorectal cancer. Expert Opin Drug Saf. 2006, 5: 553-566. 10.1517/14740338.5.4.553.CrossRefPubMed Saif MW, Mehra R: Incidence and management of bevacizumab-related toxicities in colorectal cancer. Expert Opin Drug Saf. 2006, 5: 553-566. 10.1517/14740338.5.4.553.CrossRefPubMed
10.
Metadata
Title
Intraarticular hemorrhage due to bevacizumab in a patient with metastatic colorectal cancer: a case report
Authors
Mukremin Uysal
Sema Sezgin Goksu
Hasan Senol Coskun
Burhan Savas
Mustafa Ozdogan
Hakan Bozcuk
Publication date
01-12-2012
Publisher
BioMed Central
Published in
Journal of Medical Case Reports / Issue 1/2012
Electronic ISSN: 1752-1947
DOI
https://doi.org/10.1186/1752-1947-6-188

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