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14-03-2022 | Intoxication | Letter to the Editor

Comparison of serum and whole blood concentrations in quetiapine overdose cases

Authors: Takeshi Saito, Tomoatsu Tsuji, Akira Namera, Seiji Morita, Yoshihide Nakagawa

Published in: Forensic Toxicology | Issue 2/2022

Abstract

This study aimed to compare whole blood and serum concentrations of quetiapine in acute poisoning cases. Authentic whole blood and respective serum samples were routinely collected from patients diagnosed with blood poisoning at our University Hospital. Accordingly, whole blood and serum paired samples from nine patients (one male and eight female patients) were analyzed for quetiapine using liquid chromatography-mass spectrometry (LC–MS). Quetiapine concentrations in whole blood and serum samples ranged widely from 5.4 to 2780 ng/mL and 9.9 to 2500 ng/mL, respectively. The whole blood/serum concentration ratio was 0.5–1.1 and increased together with an increase in whole blood and serum quetiapine concentrations. The ratio was reversed at around 2500 ng/mL to > 1. Our findings suggest that whole blood concentrations are more useful than serum concentrations in diagnosing quetiapine poisonings.

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Title: Comparison of serum and whole blood concentrations in quetiapine overdose cases
Authors: Takeshi Saito
Tomoatsu Tsuji
Akira Namera
Seiji Morita
Yoshihide Nakagawa
Publication date: 14-03-2022
Publisher: Springer Nature Singapore
Keywords: Intoxication
Quetiapine
Published in: Forensic Toxicology / Issue 2/2022
Print ISSN: 1860-8965
Electronic ISSN: 1860-8973
DOI: https://doi.org/10.1007/s11419-022-00618-w

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Comparison of serum and whole blood concentrations in quetiapine overdose cases

Abstract

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