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European Spine Journal
Published in: European Spine Journal 4/2008

01-12-2008 | Review

Intervertebral disc transplantation: a biological approach to motion preservation

Authors: Keith D. K. Luk, D. K. Ruan

Published in: European Spine Journal | Special Issue 4/2008

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Abstract

Intervertebral disc transplantation was developed in a bipedal animal model through the stages of autograft, fresh allograft and fresh frozen allograft. Results showed that the allografts were able to survive through a deep freezing protocol and maintain cell viability after transplantation without significant immunoreaction. Although degeneration of the allograft appeared to be inevitable, it was able to maintain stability and mobility of the functional spinal unit. These findings were similarly reproduced in the human clinical trial with excellent mid-term clinical results at 5 years. The process of evolution and findings were summarized in this review.
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Metadata
Title
Intervertebral disc transplantation: a biological approach to motion preservation
Authors
Keith D. K. Luk
D. K. Ruan
Publication date
01-12-2008
Publisher
Springer-Verlag
Published in
European Spine Journal / Issue Special Issue 4/2008
Print ISSN: 0940-6719
Electronic ISSN: 1432-0932
DOI
https://doi.org/10.1007/s00586-008-0748-0

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