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International Urogynecology Journal

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01-06-2010 | Original Article

Interposition grafts for rectovaginal fistula repair in the New Zealand white rabbit

Authors: Matthew J. Aungst, Jeremy J. Bearss, Bridget S. Lewis, John R. Fischer, Michael R. Bonhage, Johnnie Wright Jr.

Published in: International Urogynecology Journal | Issue 6/2010

Abstract

Introduction and hypothesis

The objective was to use an animal model to study different types of interposition grafts for rectovaginal fistula repair.

Methods

Twelve New Zealand white rabbits underwent surgical creation of a rectovaginal fistula, followed by repair. Four repair techniques were studied; three with interposition grafts and one control group without a graft. Animals were euthanized at 4-week intervals and underwent gross and histologic analysis.

Results

The mean rectovaginal wall thickness was greatest in the control group (5.6 mm) and thinnest in the autologous rectus fascia (4.2 mm) and porcine small intestine submucosa (5.1 mm) groups. The polypropylene graft had a mean thickness of 5.4 mm and elicited a strong, protracted inflammatory response. All fistulas were successfully closed except one porcine small intestine submucosa repair.

Conclusions

There is no benefit from interposition graft use for rectovaginal fistula repair in our New Zealand white rabbit model.

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Title: Interposition grafts for rectovaginal fistula repair in the New Zealand white rabbit
Authors: Matthew J. Aungst
Jeremy J. Bearss
Bridget S. Lewis
John R. Fischer
Michael R. Bonhage
Johnnie Wright Jr.
Publication date: 01-06-2010
Publisher: Springer-Verlag
Published in: International Urogynecology Journal / Issue 6/2010
Print ISSN: 0937-3462
Electronic ISSN: 1433-3023
DOI: https://doi.org/10.1007/s00192-010-1096-2

At a glance: The STEP trials

Springer Medicine

Interposition grafts for rectovaginal fistula repair in the New Zealand white rabbit

Abstract

Introduction and hypothesis

Methods

Results

Conclusions

At a glance: The STEP trials

Springer Medicine

Abstract

Introduction and hypothesis

Methods

Results

Conclusions

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