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Journal of Children's Orthopaedics

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01-06-2008 | Basic Science

Internal device decreases antibiotic’s efficacy on experimental osteomyelitis

Authors: Antoine Hamel, Jocelyne Caillon, Cédric Jacqueline, Jean-Michel Rogez, Gilles Potel

Published in: Journal of Children's Orthopaedics | Issue 3/2008

Abstract

Purpose

We have evaluated the effect of internal and external osteosynthesis devices on the efficacy of vancomycin treatment in a rabbit model of methicillin-resistant Staphylococcus aureus (MRSA)-induced post-traumatic osteomyelitis.

Methods

Double tibial osteotomies in female New Zealand rabbits were performed, inoculated with a MRSA strain, then fixed with an intramedullary rod. A debridement was performed 4 days later for each rabbit, and a bacterial count in pus was determined (B1). In the first group (G1), the osteosynthesis material was removed and replaced by a new sterile nail. In the second group (G2), the intramedullary rod was removed and then replaced by an external fixator. Immediately after surgery, G1 and G2 rabbits were treated with vancomycin (60 mg/kg twice a day). The animals were sacrificed at the end of a 5-day period, and a bacterial count in pus was performed again (B2).

Results

The difference of log₁₀ colony forming units per milliliter (CFU/ml) (B2−B1) was −1.2 ± 0.5 and −2.9 ± 1.1, respectively, for G1 and G2.

Conclusion

The efficacy of vancomycin treatment increased after removal of the internal osteosynthesis device.

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Title: Internal device decreases antibiotic’s efficacy on experimental osteomyelitis
Authors: Antoine Hamel
Jocelyne Caillon
Cédric Jacqueline
Jean-Michel Rogez
Gilles Potel
Publication date: 01-06-2008
Publisher: Springer Berlin Heidelberg
Published in: Journal of Children's Orthopaedics / Issue 3/2008
Print ISSN: 1863-2521
Electronic ISSN: 1863-2548
DOI: https://doi.org/10.1007/s11832-008-0102-4

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Internal device decreases antibiotic’s efficacy on experimental osteomyelitis

Abstract

Purpose

Methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusion

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