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01-12-2008 | Basic Science

Intermittent active motion versus immobilization in the treatment of Staphylococcus aureus-induced arthritis in a rabbit model

Authors: Antoine Hamel, Jocelyne Caillon, Cédric Jacqueline, Eric Batard, David Boutoille, Denis Bugnon, Anne-Françoise Miégeville, Jean-Michel Rogez, Gilles Potel

Published in: Journal of Children's Orthopaedics | Issue 6/2008

Abstract

Purpose

This study has evaluated the effects of immobilization versus intermittent active motion on cartilage and on antibiotic efficacy in a rabbit septic arthritis model.

Methods

Rabbits were infected and assigned to one of four groups: group 1, no treatment without immobilization (allowing intermittent active motion); group 2, cast; group 3, oxacillin without immobilization; group 4, oxacillin and cast. Animals were sacrificed 21 days later. Bacterial counts and lateral radiograms were performed. A radiological score was calculated.

Results

Immobilization had no effect on oxacillin efficacy and a deleterious effect on the radiological score.

Conclusion

Intermittent active motion has allowed a better cartilage healing during the treatment of septic arthritis.

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Title: Intermittent active motion versus immobilization in the treatment of Staphylococcus aureus-induced arthritis in a rabbit model
Authors: Antoine Hamel
Jocelyne Caillon
Cédric Jacqueline
Eric Batard
David Boutoille
Denis Bugnon
Anne-Françoise Miégeville
Jean-Michel Rogez
Gilles Potel
Publication date: 01-12-2008
Publisher: Springer Berlin Heidelberg
Published in: Journal of Children's Orthopaedics / Issue 6/2008
Print ISSN: 1863-2521
Electronic ISSN: 1863-2548
DOI: https://doi.org/10.1007/s11832-008-0128-7

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Intermittent active motion versus immobilization in the treatment of Staphylococcus aureus-induced arthritis in a rabbit model

Abstract

Purpose

Methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusion

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