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Journal of Translational Medicine
Published in: Journal of Translational Medicine 1/2010

Open Access 01-11-2010 | Poster presentation

Interleukin-1-induced cyclooxygenase-2 and inducible nitric oxide synthase expression in human OA chondrocytes is associated with histone H3K4 methylation

Authors: N Chabane, N Zayed, J Martel-Pelletier, J P Pelletier, H Fahmi

Published in: Journal of Translational Medicine | Special Issue 1/2010

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Excerpt

Increased expression of inducible NO synthase (iNOS) and cyclooxygenase (COX)-2 plays a key role in the pathogenesis of osteoarthritis (OA) disease. Methylation of lysine 4 on histone H3 (H3K4) was shown to be of fundamental importance in the regulation of gene expression. In the present study, we investigated the role of H3K4 methylation in interleukin-1β (IL-1)-induced COX-2 and iNOS expression in human OA chondrocytes. …
Metadata
Title
Interleukin-1-induced cyclooxygenase-2 and inducible nitric oxide synthase expression in human OA chondrocytes is associated with histone H3K4 methylation
Authors
N Chabane
N Zayed
J Martel-Pelletier
J P Pelletier
H Fahmi
Publication date
01-11-2010
Publisher
BioMed Central
Published in
Journal of Translational Medicine / Issue Special Issue 1/2010
Electronic ISSN: 1479-5876
DOI
https://doi.org/10.1186/1479-5876-8-S1-P59

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Keynote webinar | Spotlight on medication adherence

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Live: Thursday 27th June 2024, 18:00-19:30 (CEST)

WHO estimates that half of all patients worldwide are non-adherent to their prescribed medication. The consequences of poor adherence can be catastrophic, on both the individual and population level.

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Prof. Kevin Dolgin
Prof. Florian Limbourg
Prof. Anoop Chauhan
Developed by: Springer Medicine
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