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01-04-2013 | Short Communication

Interleukin-1 family members are enhanced in psoriasis and suppressed by vitamin D and retinoic acid

Authors: Anna Balato, Maria Schiattarella, Serena Lembo, Martina Mattii, Nella Prevete, Nicola Balato, Fabio Ayala

Published in: Archives of Dermatological Research | Issue 3/2013

Abstract

Interleukin (IL)-1 family comprise 11 members that play an important role in immune regulation and inflammatory process. Retinoids exert complex effects on the immune system, having anti-inflammatory effects in chronic dermatological diseases. Vitamin D (vitD) and analogs have been shown to suppress TNF-α-induced IL-1α in human keratinocytes (KCs). In the present study, we investigated IL-1 family members in psoriasis and the effects of vitD and retinoic acid (RA) on these members. We analyzed IL-1 family members gene expression in psoriatic skin and in ex vivo skin organ culture exposed to TNF-α, IL-17 or broadband UVB; afterwards, treatment with vitD or RA was performed and IL-1 family members mRNA was evaluated. Similarly, KCs were stimulated with IL-17 and subsequently treated with vitD. IL-1 family members were enhanced in psoriatic skin and in ex vivo skin organ cultures after pro-inflammatory stimuli (TNF-α, IL-17 and UVB). RA and vitD were able to suppress this enhancement.

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Title: Interleukin-1 family members are enhanced in psoriasis and suppressed by vitamin D and retinoic acid
Authors: Anna Balato
Maria Schiattarella
Serena Lembo
Martina Mattii
Nella Prevete
Nicola Balato
Fabio Ayala
Publication date: 01-04-2013
Publisher: Springer-Verlag
Published in: Archives of Dermatological Research / Issue 3/2013
Print ISSN: 0340-3696
Electronic ISSN: 1432-069X
DOI: https://doi.org/10.1007/s00403-013-1327-8

At a glance: The STEP trials

Springer Medicine

Interleukin-1 family members are enhanced in psoriasis and suppressed by vitamin D and retinoic acid

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

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