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01-09-2017 | Original Article

Interhemispheric gene expression differences in the cerebral cortex of humans and macaque monkeys

Authors: Gerard Muntané, Gabriel Santpere, Andrey Verendeev, William W. Seeley, Bob Jacobs, William D. Hopkins, Arcadi Navarro, Chet C. Sherwood

Published in: Brain Structure and Function | Issue 7/2017

Abstract

Handedness and language are two well-studied examples of asymmetrical brain function in humans. Approximately 90% of humans exhibit a right-hand preference, and the vast majority shows left-hemisphere dominance for language function. Although genetic models of human handedness and language have been proposed, the actual gene expression differences between cerebral hemispheres in humans remain to be fully defined. In the present study, gene expression profiles were examined in both hemispheres of three cortical regions involved in handedness and language in humans and their homologues in rhesus macaques: ventrolateral prefrontal cortex, posterior superior temporal cortex (STC), and primary motor cortex. Although the overall pattern of gene expression was very similar between hemispheres in both humans and macaques, weighted gene correlation network analysis revealed gene co-expression modules associated with hemisphere, which are different among the three cortical regions examined. Notably, a receptor-enriched gene module in STC was particularly associated with hemisphere and showed different expression levels between hemispheres only in humans.

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Title: Interhemispheric gene expression differences in the cerebral cortex of humans and macaque monkeys
Authors: Gerard Muntané
Gabriel Santpere
Andrey Verendeev
William W. Seeley
Bob Jacobs
William D. Hopkins
Arcadi Navarro
Chet C. Sherwood
Publication date: 01-09-2017
Publisher: Springer Berlin Heidelberg
Published in: Brain Structure and Function / Issue 7/2017
Print ISSN: 1863-2653
Electronic ISSN: 1863-2661
DOI: https://doi.org/10.1007/s00429-017-1401-7

At a glance: The STEP trials

Springer Medicine

Interhemispheric gene expression differences in the cerebral cortex of humans and macaque monkeys

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

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