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Open Access 01-12-2012 | Research article

Interactive effect of genetic susceptibility with height, body mass index, and hormone replacement therapy on the risk of breast cancer

Authors: Sophia Harlid, Salma Butt, Malin IL Ivarsson, Jorunn Erla Eyfjörd, Per Lenner, Jonas Manjer, Joakim Dillner, Joyce Carlson

Published in: BMC Women's Health | Issue 1/2012

Abstract

Background

Breast cancer today has many established risk factors, both genetic and environmental, but these risk factors by themselves explain only part of the total cancer incidence. We have investigated potential interactions between certain known genetic and phenotypic risk factors, specifically nine single nucleotide polymorphisms (SNPs) and height, body mass index (BMI) and hormone replacement therapy (HRT).

Methods

We analyzed samples from three different study populations: two prospectively followed Swedish cohorts and one Icelandic case–control study. Totally 2884 invasive breast cancer cases and 4508 controls were analysed in the study. Genotypes were determined using Mass spectrometry-Maldi-TOF and phenotypic variables were derived from measurements and/or questionnaires. Odds Ratios and 95% confidence intervals were calculated using unconditional logistic regression with the inclusion of an interaction term in the logistic regression model.

Results

One SNP (rs851987 in ESR1) tended to interact with height, with an increasingly protective effect of the major allele in taller women (p = 0.007) and rs13281615 (on 8q24) tended to confer risk only in non users of HRT (p-for interaction = 0.03). There were no significant interactions after correction for multiple testing.

Conclusions

We conclude that much larger sample sets would be necessary to demonstrate interactions between low-risk genetic polymorphisms and the phenotypic variables height, BMI and HRT on the risk for breast cancer. However the present hypothesis-generating study has identified tendencies that would be of interest to evaluate for gene-environment interactions in independent materials.

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The pre-publication history for this paper can be accessed here:http://www.biomedcentral.com/1472-6874/12/17/prepub

Title: Interactive effect of genetic susceptibility with height, body mass index, and hormone replacement therapy on the risk of breast cancer
Authors: Sophia Harlid
Salma Butt
Malin IL Ivarsson
Jorunn Erla Eyfjörd
Per Lenner
Jonas Manjer
Joakim Dillner
Joyce Carlson
Publication date: 01-12-2012
Publisher: BioMed Central
Published in: BMC Women's Health / Issue 1/2012
Electronic ISSN: 1472-6874
DOI: https://doi.org/10.1186/1472-6874-12-17

At a glance: The STEP trials

Springer Medicine

Interactive effect of genetic susceptibility with height, body mass index, and hormone replacement therapy on the risk of breast cancer

Abstract

Background

Methods

Results

Conclusions

At a glance: The STEP trials

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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