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Intensive Care Medicine
Published in: Intensive Care Medicine 7/2007

01-07-2007 | Correspondence

Intensive insulin therapy in the ICU: benefit versus harm?

Authors: F. M. Brunkhorst, K. Reinhart

Published in: Intensive Care Medicine | Issue 7/2007

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Excerpt

Sir: We read with interest the recent publication by Van den Berghe et al. on pooled subgroup analyses of data from two single-center intervention studies on the ICU regarding the potential benefit or harm of intensive insulin therapy (IIT) [1]. Some of the presented analyses aroused our concern, however, because definitions and methods need to be explained to clinicians not actively involved in critical care, and the resulting conclusions partly contradict published results from the original articles of this study group [2, 3]. …
Literature
1.
van den Berghe G, Wilmer A, Milants I, Wouters PJ, Bouckaert B, Bruyninckx F, Bouillon R, Schetz M (2006) Intensive insulin therapy in mixed medical/surgical intensive care units: benefit versus harm. Diabetes 55:3151–3159CrossRefPubMed
2.
van den Berghe G, Wilmer A, Hermans G, Meersseman W, Wouters PJ, Milants I, Van Wijngaerden E, Bobbaers H, Bouillon R (2006) Intensive insulin therapy in the medical ICU. N Engl J Med 354:449–461CrossRefPubMed
3.
van den Berghe G, Wouters P, Weekers F, Verwaest C, Bruyninckx F, Schets M, Vlasselaers D, Ferdinande P, Lauwers P, Bouillon R (2001) Intensive insulin therapy in the critically ill patients. N Engl J Med 345:1359–1367CrossRefPubMed
4.
Brunkhorst F, Kuhnt E, Engel C, Meier-Hellmann A, Ragaller M, Quintel M et al. (2005) Intensive insulin therapy in patient with severe sepsis and septic shock is associated with an increased rate of hypoglycemia – results from a randomized multicenter study (VISEP). Infection 33:19–20
Metadata
Title
Intensive insulin therapy in the ICU: benefit versus harm?
Authors
F. M. Brunkhorst
K. Reinhart
Publication date
01-07-2007
Publisher
Springer Berlin Heidelberg
Published in
Intensive Care Medicine / Issue 7/2007
Print ISSN: 0342-4642
Electronic ISSN: 1432-1238
DOI
https://doi.org/10.1007/s00134-007-0648-5

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