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Open Access 17-08-2023 | Intense Pulsed Light | ORIGINAL RESEARCH

The Combined Impact of Intense Pulsed Light Combined and 3% Diquafosol Ophthalmic Solution on Evaporative Dry Eye: A Randomized Control Study

Authors: Jiayan Chen, Guanghao Qin, Liangzhe Li, Yifan Qi, Yang Xia, Qing Zhang, Yi Wu, Yue You, Lanting Yang, Naici Guo, Salissou Moutari, Jonathan E. Moore, Shaochong Bu, Ling Xu, Wei He, Sile Yu, Emmanuel Eric Pazo, Xingru He

Published in: Ophthalmology and Therapy | Issue 6/2023

Abstract

Introduction

The primary objective of this study is to assess whether the combination of intense pulsed light (IPL) with 3% diquafosol (DQS) ophthalmic solution is more effective than intense pulsed light in alleviating signs and symptoms of dry eye disease (DED).

Methods

This randomized study included 66 participants with evaporative dry eye (EDE) who received IPL + DQS therapy (n = 44 eyes), IPL therapy (n = 44 eyes), or sham therapy (n = 44 eyes). All participants were examined at baseline (D0), day 14 (D14), and day 28 (D28) for non-invasive break-up time (NITBUT), tear-film lipid layer (TFLL), corneal conjunctival staining (CS), meibomian gland quality (MGQ), meibomian gland expression (MGEx), and ocular surface disease index (OSDI).

Results

At day 28, comparison among the IPL + DQS therapy, IPL therapy, and sham therapy found significant differences in the mean NITBUT (12.03 ± 1.27 versus 10.47 ± 3.48 versus 4.57 ± 0.46; p < 0.001), TFLL (2.09 ± 0.29 versus 2.27 ± 0.45 versus 2.89 ± 0.65; p < 0.001), CS (1.43 ± 0.82 versus 1.93 ± 1.32 versus 3.52 ± 1.00; p < 0.001), MGQ (1.55 ± 0.66 versus 1.91 ± 0.77 versus 2.66 ± 0.53; p < 0.001), MGEx (1.27 ± 0.45 versus 1.75 ± 0.44 versus 2.41 ± 0.50; p < 0.001), and OSDI score (19.36 ± 7.01 versus 24.77 ± 4.68 versus 42.61 ± 7.49; p < 0.001); significant improvements in NITBUT, TFLL, CS, MGQ, MGEx, and OSDI were found in the IPL + DQS therapy and IPL therapy, while the sham therapy had no significant improvements.

Conclusion

Combining 3% diquafosol ophthalmic solution with intense pulsed light was superior to IPL therapy alone in relieving the signs and symptoms of patients with severe evaporative DED.

Trial registration

Clinical Trials Identifier: NCT05694026

Available only for authorised users

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Title: The Combined Impact of Intense Pulsed Light Combined and 3% Diquafosol Ophthalmic Solution on Evaporative Dry Eye: A Randomized Control Study
Authors: Jiayan Chen
Guanghao Qin
Liangzhe Li
Yifan Qi
Yang Xia
Qing Zhang
Yi Wu
Yue You
Lanting Yang
Naici Guo
Salissou Moutari
Jonathan E. Moore
Shaochong Bu
Ling Xu
Wei He
Sile Yu
Emmanuel Eric Pazo
Xingru He
Publication date: 17-08-2023
Publisher: Springer Healthcare
Keywords: Intense Pulsed Light
Xerophthalmia
Published in: Ophthalmology and Therapy / Issue 6/2023
Print ISSN: 2193-8245
Electronic ISSN: 2193-6528
DOI: https://doi.org/10.1007/s40123-023-00784-z

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