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01-11-2008 | Original Article

Integrin-linked kinase cytoplasmic and nuclear expression in laryngeal carcinomas

Authors: Anastasios K. Goulioumis, Vasiliki Bravou, John Varakis, Panos Goumas, Helen Papadaki

Published in: Virchows Archiv | Issue 5/2008

Abstract

Integrin-linked kinase (ILK) has been implicated in the development and progression of several human malignancies. Previous in vitro studies also implicate ILK in the activation of Akt and β-catenin as well as in the regulation of E-cadherin expression. However, the role of ILK in human laryngeal cancer and its possible in vivo downstream effectors in the disease are currently unknown. We examined by immunohistochemistry the protein expression of ILK, phosphorylated-Akt (p-Akt), E-cadherin, and β-catenin in 97 invasive squamous laryngeal carcinomas. Increased cytoplasmic and nuclear expression of ILK and p-Akt decreased membranous expression of E-cadherin and nuclear accumulation of β-catenin was found in 87.6%, 85.6%, 71.1%, and 43.3% of cases, respectively. Our results suggest that ILK expression may be implicated in human laryngeal carcinoma and its localization in the nucleus possibly proposes novel nuclear functions of this molecule. In addition, enhanced ILK expression correlates with activation of Akt but not with downregulation of E-cadherin and activation of β-catenin. Finally, in our material while activated Akt seems to characterize well-differentiated tumors, loss of E-cadherin and activation of β-catenin correlated with high grade carcinomas.

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Title: Integrin-linked kinase cytoplasmic and nuclear expression in laryngeal carcinomas
Authors: Anastasios K. Goulioumis
Vasiliki Bravou
John Varakis
Panos Goumas
Helen Papadaki
Publication date: 01-11-2008
Publisher: Springer-Verlag
Published in: Virchows Archiv / Issue 5/2008
Print ISSN: 0945-6317
Electronic ISSN: 1432-2307
DOI: https://doi.org/10.1007/s00428-008-0668-8

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Integrin-linked kinase cytoplasmic and nuclear expression in laryngeal carcinomas

Abstract

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Abstract

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