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Osteoporosis International

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01-10-2017 | Original Article

Intake of omega-3 fatty acids contributes to bone mineral density at the hip in a younger Japanese female population

Authors: T. Kuroda, H. Ohta, Y. Onoe, N. Tsugawa, M. Shiraki

Published in: Osteoporosis International | Issue 10/2017

Abstract

Summary

This study investigated the relationships between intakes of polyunsaturated fatty acids, omega-3 fatty acids, and omega-6 fatty acids and bone mineral density in Japanese women aged 19 to 25 years. Intakes of omega-3 fatty acids (n-3) were positively associated with peak bone mass at the hip.

Introduction

Lifestyle factors such as physical activity and nutrition intake are known to optimize the peak bone mass (PBM). Recently, intake of polyunsaturated fatty acids (PUFAs) has been reported to contribute to bone metabolism. In this study, the relationships of intakes of n-3 and omega-6 (n-6) fatty acids with PBM were evaluated in Japanese female subjects.

Methods

A total of 275 healthy female subjects (19–25 years) having PBM were enrolled, and lumbar and total hip bone mineral density (BMD) and bone metabolic parameters were measured. Dietary intakes of total energy, total n-3 fatty acids, eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), and total n-6 fatty acids were assessed by a self-administered questionnaire. Physical activity information was also assessed.

Results

The mean ± SD age was 20.6 ± 1.4 years, and BMI was 21.2 ± 2.7 kg/m². BMI and serum bone alkaline phosphatase contributed significantly to lumbar BMD on multiple regression analysis. Intake of n-3 fatty acids and physical activity were also significantly related to total hip BMD. Using EPA or DHA instead of total n-3 fatty acids in the model did not result in a significant result.

Conclusion

Adequate total n-3 fatty acid intake may help maximize PBM at the hip.

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Title: Intake of omega-3 fatty acids contributes to bone mineral density at the hip in a younger Japanese female population
Authors: T. Kuroda
H. Ohta
Y. Onoe
N. Tsugawa
M. Shiraki
Publication date: 01-10-2017
Publisher: Springer London
Published in: Osteoporosis International / Issue 10/2017
Print ISSN: 0937-941X
Electronic ISSN: 1433-2965
DOI: https://doi.org/10.1007/s00198-017-4128-7

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Intake of omega-3 fatty acids contributes to bone mineral density at the hip in a younger Japanese female population

Abstract

Summary

Introduction

Methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Summary

Introduction

Methods

Results

Conclusion

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