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European Journal of Medical Research

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Open Access 01-12-2023 | Insulins | Research

HOMA-IR is positively correlated with biological age and advanced aging in the US adult population

Authors: Haifang Yang, Rongpeng Gong, Moli Liu, Ying Deng, Xiaoyu Zheng, Tianyang Hu

Published in: European Journal of Medical Research | Issue 1/2023

Abstract

Background

Insulin resistance (IR) had been reported to be associated with age; however, few studies have explored the association between IR and biological age (BA). The HOMA-IR value is a useful indicator of the extent of IR. This cross-sectional study is to explore the relationship between HOMA-IR and BA/advanced aging in the US population.

Methods

This study is a cross-sectional analysis of National Health and Nutrition Examination Survey (NHANES) data. The survey comprised 12,266 people from the NHANES, and their full HOMA-IR data as well as BA data were extracted. Four multiple linear regressions were performed to analyze the association between HOMA-IR and BA, and four multiple logistic regression models were performed to analyze the association between HOMA-IR and advanced aging. In addition, trend tests and stratified analysis were performed and smoothed fitted curves were plotted to test the robustness of the results.

Results

HOMA-IR was positively correlated with BA [β: 0.51 (0.39, 0.63)], and it was the same to advanced aging [OR: 1.05 (1.02, 1.07)], and both showed a monotonically increasing trend. The trend tests showed that the results were stable (all P for trend < 0.0001). The smoothed fitted curves showed that there were non-linear relationships between HOMA-IR and BA/advanced aging. And the stratified analysis indicated that the relationship between HOMA-IR and BA/advanced aging remained robust in all subgroups.

Conclusion

The study suggested that HOMA-IR is positively correlated with BA and advanced aging in the US adult population, with a monotonic upward trend. This is a new finding to reveal the relationship between HOMA-IR and age from new standpoint of BA rather than chronological age (CA). And it may contribute to a better understanding of human health aging and may aid future research in this field.

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Title: HOMA-IR is positively correlated with biological age and advanced aging in the US adult population
Authors: Haifang Yang
Rongpeng Gong
Moli Liu
Ying Deng
Xiaoyu Zheng
Tianyang Hu
Publication date: 01-12-2023
Publisher: BioMed Central
Keywords: Insulins
Insulins
Published in: European Journal of Medical Research / Issue 1/2023
Electronic ISSN: 2047-783X
DOI: https://doi.org/10.1186/s40001-023-01448-1

Keynote webinar | Spotlight on medication adherence

Springer Medicine

HOMA-IR is positively correlated with biological age and advanced aging in the US adult population

Abstract

Background

Methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusion

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