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Journal of Diabetes & Metabolic Disorders
Published in: Journal of Diabetes & Metabolic Disorders 1/2023

13-02-2023 | Insulins | Research article

Association between serum interleukin-6, leptin and insulin in gestational diabetes mellitus – a cross- sectional study

Authors: Neha Srivastava, Kalpana Singh, Nisha Singh, Abbas Ali Mahdi

Published in: Journal of Diabetes & Metabolic Disorders | Issue 1/2023

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Abstract

Purpose

Gestational diabetes mellitus (GDM) is a state of leptin resistance which develops a vicious cycle of hyperinsulinemia and hyperleptinemia leading to aggravation of an inflammatory situation. This study was done to find out the association between IL-6, leptin and insulin in gestational diabetes among North Indian women.

Method

This cross-sectional study included 100 GDM, 100 non-GDM and 50 non-pregnant women. DIPSI (Diabetes in Pregnancy Study Group India) criteria was used for screening GDM among pregnant women. GDM and non-GDM pregnant women were further categorized into three groups according to the trimester of pregnancy. Serum IL-6, leptin and insulin were measured in all the enrolled women.

Results

Serum IL-6 levels were significantly higher among GDM women as compared to non-GDM and non-pregnant women. Although the mean serum leptin and insulin levels were higher in GDM, but the difference was not statistically significant. When GDM and non-GDM women were categorized into three trimester, serum leptin levels were found to be significantly higher in 3rd trimester (p < 0.002) and IL-6 in 1st trimester (p < 0.017) among GDM women. No correlation was found between serum IL-6, leptin and insulin in GDM.

Conclusion

Absence of any significant association between leptin and IL-6 signifies that leptin may not be associated with inflammation in gestational diabetes. However, IL-6 may serve as an early marker for screening glucose intolerance during pregnancy.
Appendix
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Metadata
Title
Association between serum interleukin-6, leptin and insulin in gestational diabetes mellitus – a cross- sectional study
Authors
Neha Srivastava
Kalpana Singh
Nisha Singh
Abbas Ali Mahdi
Publication date
13-02-2023
Publisher
Springer International Publishing
Published in
Journal of Diabetes & Metabolic Disorders / Issue 1/2023
Electronic ISSN: 2251-6581
DOI
https://doi.org/10.1007/s40200-023-01188-3

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