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Open Access 21-04-2023 | Insulins | Original Article

Gastrectomy reduces pancreatic secretory function via pancreatic atrophy

Authors: Shumpei Satoi, Yutaka Kimura, Rie Shimizu, Masataka Matsumoto, Kohei Kawaguchi, Yuta Yoshida, Takaaki Murase, Keiko Kamei, Ippei Matsumoto, Takuya Nakai, Yoshifumi Takeyama

Published in: Surgery Today | Issue 12/2023

Abstract

Purpose

Although reports suggest that the pancreatic volume decreases after gastrectomy for gastric cancer, the relationship between the pancreatic volume and secretory function after gastrectomy remains unclear. In this study, we examined the relationship between the pancreatic volume and exocrine and endocrine functions after total gastrectomy.

Methods

The pancreatic volumes of 18 distal gastrectomy and 15 total gastrectomy patients were retrospectively measured using computed tomography volumetry up to 5 years postoperatively. Ten low anterior resection patients were selected as controls. In addition, the pancreatic volume and exocrine function evaluated by fecal elastase and the insulin secretory function evaluated by glucagon tolerance testing were prospectively examined before and one year after surgery in nine cases of total gastrectomy.

Results

After low anterior resection, the pancreatic volume did not change, but after distal and total gastrectomy, the pancreatic volume decreased continuously until the fifth year. After total gastrectomy, fecal elastase decreased significantly from 865.8 μg/g to 603.2 μg/g in the first year (p = 0.0316), and the insulin secretion capacity also decreased significantly from 3.83 ng/mL to 2.26 ng/mL (p = 0.0019).

Conclusions

The pancreatic volume decreases continuously after gastrectomy for gastric cancer, and the pancreatic exocrine and endocrine functions decrease along with pancreatic atrophy after total gastrectomy.

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Title: Gastrectomy reduces pancreatic secretory function via pancreatic atrophy
Authors: Shumpei Satoi
Yutaka Kimura
Rie Shimizu
Masataka Matsumoto
Kohei Kawaguchi
Yuta Yoshida
Takaaki Murase
Keiko Kamei
Ippei Matsumoto
Takuya Nakai
Yoshifumi Takeyama
Publication date: 21-04-2023
Publisher: Springer Nature Singapore
Keywords: Insulins
Gastrectomy
Gastric Cancer
Gastric Cancer
Gastrectomy
Insulins
Published in: Surgery Today / Issue 12/2023
Print ISSN: 0941-1291
Electronic ISSN: 1436-2813
DOI: https://doi.org/10.1007/s00595-023-02685-x

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Gastrectomy reduces pancreatic secretory function via pancreatic atrophy

Abstract

Purpose

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusions

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