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BMC Public Health
Published in: BMC Public Health 1/2020

Open Access 01-12-2020 | Insulins | Research article

Height predict incident non-alcoholic fatty liver disease among general adult population in Tianjin, China, independent of body mass index, waist circumference, waist-to-height ratio, and metabolic syndrome

Authors: Shubham Kumari, Xuena Wang, Yunyun Liu, Yeqing Gu, Yuhan Huang, Qing Zhang, Li Liu, Ge Meng, Hongmei Wu, Shaomei Sun, Xing Wang, Ming Zhou, Qiyu Jia, Guolin Wang, Kun Song, Kaijun Niu

Published in: BMC Public Health | Issue 1/2020

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Abstract

Background

Early-life hormonal and nutritional factors can greatly influence the risk of non-alcoholic fatty liver disease (NAFLD). Adult height is a simple marker for these factors. This study aimed to investigate the association between adult height and NAFLD.

Methods

We performed a prospective cohort study of 35,994 participants aged 25 years or over with measured height at baseline. NAFLD was diagnosed by abdominal ultrasound and self-reported history of alcohol intake. Multivariable Cox proportional hazards regression models were conducted to assess the gender-specific association between height and the risk of NAFLD.

Results

During a follow-up period of 5.5 years, 6245 of 35,994 subjects developed NAFLD. The adjusted hazard ratios (95% confidence interval) of NAFLD for increasing quintiles of height were 1.00 (reference), 0.82 (0.73, 0.92), 0.84 (0.73, 0.97), 0.72 (0.61, 0.85) and 0.63 (0.50, 0.79) (P for trend < 0.0001) in males, and 1.00 (reference), 1.00 (reference), 0.80 (0.69, 0.91), 0.72 (0.61, 0.85), 0.60 (0.49, 0.74) and 0.45 (0.35, 0.59) (P for trend < 0.0001) in females, respectively.

Conclusions

A higher adult height was associated with lower risk of NAFLD among males and females in Tianjin, China.
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Metadata
Title
Height predict incident non-alcoholic fatty liver disease among general adult population in Tianjin, China, independent of body mass index, waist circumference, waist-to-height ratio, and metabolic syndrome
Authors
Shubham Kumari
Xuena Wang
Yunyun Liu
Yeqing Gu
Yuhan Huang
Qing Zhang
Li Liu
Ge Meng
Hongmei Wu
Shaomei Sun
Xing Wang
Ming Zhou
Qiyu Jia
Guolin Wang
Kun Song
Kaijun Niu
Publication date
01-12-2020
Publisher
BioMed Central
Published in
BMC Public Health / Issue 1/2020
Electronic ISSN: 1471-2458
DOI
https://doi.org/10.1186/s12889-020-08475-1

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