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Published in:

01-10-2016

Innate defense mechanisms against HSV-1 infection in the target tissues, skin and brain

Authors: Yael Tsalenchuck, Israel Steiner, Amos Panet

Published in: Journal of NeuroVirology | Issue 5/2016

Abstract

Herpes simplex virus type 1 (HSV-1) initiates productive infection in mucocutaneous tissues to cause cold sores and establishes latent infection in the trigeminal ganglia. Under certain circumstances, HSV-1 may cause encephalitis. Here, we compared host innate defenses against HSV-1 in the two clinically relevant tissues, skin and brain, using a unique ex vivo system of organ culture. Upon HSV-1 infection and spread, apoptosis induction was observed in the skin, but not in brain tissues. While the two tissues elicited interferon (IFN-β) response upon HSV1 infection, IFN induction was more robust in the skin compared to the brain. Moreover, antiviral response to exogenous IFNβ treatment was much stronger in the skin compared to brain tissues. This observation was not related to the availability of the IFN receptor on cells’ surface. Taken together, our study demonstrates differential innate antiviral responses to HSV-1 infection that may be exploited in future development of selective and tissue-specific anti-viral treatments.

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Title: Innate defense mechanisms against HSV-1 infection in the target tissues, skin and brain
Authors: Yael Tsalenchuck
Israel Steiner
Amos Panet
Publication date: 01-10-2016
Publisher: Springer International Publishing
Published in: Journal of NeuroVirology / Issue 5/2016
Print ISSN: 1355-0284
Electronic ISSN: 1538-2443
DOI: https://doi.org/10.1007/s13365-016-0440-9

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Innate defense mechanisms against HSV-1 infection in the target tissues, skin and brain

Abstract

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