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Aesthetic Plastic Surgery

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01-12-2021 | Injectable Filler | Original Article

Using New Autologous Tissue Filler Improved Nasolabial Folds−Single-Armed Pilot Study

Authors: Hanyi Jiang, Ying Guan, Jing Yang, Jiao Zhang, Qingguo Zhang, Zhiwei Chen

Published in: Aesthetic Plastic Surgery | Issue 6/2021

Abstract

Objective

To evaluate the clinical efficacy and safety of the new autologous tissue filler derived from autologous skin and hairs for correction of nasolabial folds.

Materials and Methods

The new injectable soft tissue filler is prepared from autologous fibroblasts and keratin gel. A total of 40 patients were enrolled in this single-armed pilot study, all of them received the new filler injection treatment for correction nasolabial folds. Following up with the patients, collection of their clinical features, including photographs, satisfaction, and information on adverse events at the 1st, 3rd, 6th, 12th, and 24th months after injection. The clinical efficacy of each patient was evaluated by masked evaluators and independent expert panels, based on the Wrinkle Severity Rating Scale (WSRS) at different time points after the injection.

Results

Thirty-two patients completed the 24-months follow-up, obtaining at least 93.8% improvement, and 75% of them had significantly improved. Base on the self-satisfaction assessment (SSA) indicated that all of them were satisfied with the results. No adverse effects of filler injection treatment were observed during the follow-up.

Conclusions

The combination of autologous keratin and fibroblasts as a new tissue engineering soft tissue filler has shown safety and long-term efficiency in correcting nasolabial folds, with high satisfaction and desirable result.

Level of Evidence IV

This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266.

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Title: Using New Autologous Tissue Filler Improved Nasolabial Folds−Single-Armed Pilot Study
Authors: Hanyi Jiang
Ying Guan
Jing Yang
Jiao Zhang
Qingguo Zhang
Zhiwei Chen
Publication date: 01-12-2021
Publisher: Springer US
Keywords: Injectable Filler
Skin Wrinkling
Published in: Aesthetic Plastic Surgery / Issue 6/2021
Print ISSN: 0364-216X
Electronic ISSN: 1432-5241
DOI: https://doi.org/10.1007/s00266-021-02608-6

At a glance: The STEP trials

Springer Medicine

Using New Autologous Tissue Filler Improved Nasolabial Folds−Single-Armed Pilot Study

Abstract

Objective

Materials and Methods

Results

Conclusions

Level of Evidence IV

At a glance: The STEP trials

Springer Medicine

Abstract

Objective

Materials and Methods

Results

Conclusions

Level of Evidence IV

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