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01-11-2013 | Translational Neurosciences - Original Article

Inhibition of protein synthesis or mTOR in the basolateral amygdala blocks retrieval-induced memory strengthening

Authors: Thiago R. Pedroso, Paulo F. C. Jobim, Leonardo M. Carvalho, Raissa R. Christoff, Natasha Maurmann, Gustavo K. Reolon, Aline Werenicz, Rafael Roesler

Published in: Journal of Neural Transmission | Issue 11/2013

Abstract

Fear memory retrieval can lead to either reconsolidation (accompanied or not by strengthening of the memory trace) or extinction. Here, we show that non-reinforced retrieval of inhibitory avoidance (IA) conditioning can induce memory strengthening assessed in a subsequent retention test trial. Infusion of the protein synthesis inhibitor cycloheximide or the mTOR inhibitor rapamycin into the rat basolateral complex of the amygdala (BLA) after a reactivation (retrieval) session impaired retrieval-induced strengthening. Intra-BLA infusion of the mRNA synthesis inhibitor 5,6-dichloro-1-beta-d-ribofuranosylbenzimidazole (DRB) after retrieval had no effect. These findings provide the first evidence suggesting that non-reinforced IA retrieval can lead to memory strengthening through a mechanism dependent on protein synthesis and mTOR activity in the BLA.

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Title: Inhibition of protein synthesis or mTOR in the basolateral amygdala blocks retrieval-induced memory strengthening
Authors: Thiago R. Pedroso
Paulo F. C. Jobim
Leonardo M. Carvalho
Raissa R. Christoff
Natasha Maurmann
Gustavo K. Reolon
Aline Werenicz
Rafael Roesler
Publication date: 01-11-2013
Publisher: Springer Vienna
Published in: Journal of Neural Transmission / Issue 11/2013
Print ISSN: 0300-9564
Electronic ISSN: 1435-1463
DOI: https://doi.org/10.1007/s00702-013-1032-y

At a glance: The STEP trials

Springer Medicine

Inhibition of protein synthesis or mTOR in the basolateral amygdala blocks retrieval-induced memory strengthening

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

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