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Journal of Occupational Medicine and Toxicology
Published in: Journal of Occupational Medicine and Toxicology 1/2010

Open Access 01-12-2010 | Research

Inhibition of gap junctional Intercellular communication in WB-F344 rat liver epithelial cells by triphenyltin chloride through MAPK and PI3-kinase pathways

Authors: Chung-Hsun Lee, I-Hui Chen, Chia-Rong Lee, Chih-Hsien Chi, Ming-Che Tsai, Jin-Lian Tsai, Hsiu-Fen Lin

Published in: Journal of Occupational Medicine and Toxicology | Issue 1/2010

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Abstract

Background

Organotin compounds (OTCs) have been widely used as stabilizers in the production of plastic, agricultural pesticides, antifoulant plaints and wood preservation. The toxicity of triphenyltin (TPT) compounds was known for their embryotoxic, neurotoxic, genotoxic and immunotoxic effects in mammals. The carcinogenicity of TPT was not well understood and few studies had discussed the effects of OTCs on gap junctional intercellular communication (GJIC) of cells.

Method

In the present study, the effects of triphenyltin chloride (TPTC) on GJIC in WB-F344 rat liver epithelial cells were evaluated, using the scrape-loading dye transfer technique.

Results

TPTC inhibited GJIC after a 30-min exposure in a concentration- and time-dependent manner. Pre-incubation of cells with the protein kinase C (PKC) inhibitor did not modify the response, but the specific MEK 1 inhibitor PD98059 and PI3K inhibitor LY294002 decreased substantially the inhibition of GJIC by TPTC. After WB-F344 cells were exposed to TPTC, phosphorylation of Cx43 increased as seen in Western blot analysis.

Conclusions

These results show that TPTC inhibits GJIC in WB-F344 rat liver epithelial cells by altering the Cx43 protein expression through both MAPK and PI3-kinase pathways.
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Metadata
Title
Inhibition of gap junctional Intercellular communication in WB-F344 rat liver epithelial cells by triphenyltin chloride through MAPK and PI3-kinase pathways
Authors
Chung-Hsun Lee
I-Hui Chen
Chia-Rong Lee
Chih-Hsien Chi
Ming-Che Tsai
Jin-Lian Tsai
Hsiu-Fen Lin
Publication date
01-12-2010
Publisher
BioMed Central
Published in
Journal of Occupational Medicine and Toxicology / Issue 1/2010
Electronic ISSN: 1745-6673
DOI
https://doi.org/10.1186/1745-6673-5-17

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