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Breast Cancer Research
Published in: Breast Cancer Research 2/2008

01-05-2008 | Poster presentation

Inhibition of apoptosis by Notch signalling in breast epithelial cells

Authors: O Meurette, S Stylianou, GM Collu, AP Gilmore, K Brennan

Published in: Breast Cancer Research | Special Issue 2/2008

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Excerpt

Aberrant Notch signalling has been shown to be involved in many cancers. We have recently observed accumulation of the Notch intracellular domain (NICD) in breast cancer cell lines and tissue samples in comparison with normal cell lines and tissues. Moreover, Notch activation has been shown to inhibit apoptosis induced by chemotherapeutics that activate the p53 pathway. We are thus investigating the role of Notch signalling in breast cancer by studying the molecular mechanisms that underlie its suppression of apoptosis. …
Metadata
Title
Inhibition of apoptosis by Notch signalling in breast epithelial cells
Authors
O Meurette
S Stylianou
GM Collu
AP Gilmore
K Brennan
Publication date
01-05-2008
Publisher
BioMed Central
Published in
Breast Cancer Research / Issue Special Issue 2/2008
Electronic ISSN: 1465-542X
DOI
https://doi.org/10.1186/bcr1904

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