Published in:
Open Access
01-10-2012 | Poster presentation
Inhibition kinetics of Plasmodium Lactate Dehydrogenase with herbal extracts suggest possible enzyme inhibitor molecular interaction
Authors:
Privadarshan Keluskar, Apeksha Mohile, Sanjay Ingle
Published in:
Malaria Journal
|
Special Issue 1/2012
Login to get access
Excerpt
Resistance acquired by Plasmodium species (especially P. falciparum) to most of the present antimalarial drugs is the principal hindrance in controlling malaria. Thus, one of the major challenges towards elimination of Malaria is development of novel and sustainable antimalarial drugs. In this milieu, herbs traditionally used to treat malaria are promising repertoires of antimalarial drugs. Earlier, lab studies have reported selective inhibition of P. falciparum and P. vivax specific Lactate Dehydrogenase (PfLDH and PvLDH) by Phyllanthus amarus aqueous extract and Murraya koenigii chloroform extract respectively. In the present investigation, we studied inhibition kinetics of PfLDH and PvLDH to explore molecular interactions between enzyme and inhibitor. …
