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Published in: Journal of Neuro-Oncology 3/2008

01-07-2008 | Clinical-patient studies

Inherent diagnostic and treatment challenges in germinoma of the basal ganglia: a case report and review of the literature

Authors: Anita Villani, Eric Bouffet, Susan Blaser, Barbara-Ann Millar, Cynthia Hawkins, Ute Bartels

Published in: Journal of Neuro-Oncology | Issue 3/2008

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Abstract

Among intracranial germinomas, basal ganglia germinomas represent a specific clinical and anatomical entity. Based on an unusual case of a basal ganglia germinoma in a 13-year-old Caucasian male, we highlight the diagnostic challenges and discuss treatment considerations in this disease.
Literature
1.
go back to reference Borg M (2003) Germ cell tumours of the central nervous system in children-controversies in radiotherapy. Med Pediatr Oncol 40:367–374PubMedCrossRef Borg M (2003) Germ cell tumours of the central nervous system in children-controversies in radiotherapy. Med Pediatr Oncol 40:367–374PubMedCrossRef
2.
go back to reference Packer RJ, Cohen BH, Cooney K (2000) Intracranial germ cell tumors. Oncologist 5:312–320PubMed Packer RJ, Cohen BH, Cooney K (2000) Intracranial germ cell tumors. Oncologist 5:312–320PubMed
3.
go back to reference Ono N, Inoue HK, Naganuma H et al (1986) Diagnosis of germinal neoplasm in the thalamus and basal ganglia. Surg Neurol 26:24–28PubMedCrossRef Ono N, Inoue HK, Naganuma H et al (1986) Diagnosis of germinal neoplasm in the thalamus and basal ganglia. Surg Neurol 26:24–28PubMedCrossRef
4.
go back to reference Yasue M, Tanaka H, Nakajima M et al (1993) Germ cell tumors of the basal ganglia and thalamus. Pediatr Neurosurg 19:121–126PubMedCrossRef Yasue M, Tanaka H, Nakajima M et al (1993) Germ cell tumors of the basal ganglia and thalamus. Pediatr Neurosurg 19:121–126PubMedCrossRef
5.
go back to reference Kobayashi H, Yamada H, Sakai N et al (1990) Germ cell tumor arising in the basal ganglia in a female–case report. Neurol Med Chir (Tokyo) 30:123–126CrossRef Kobayashi H, Yamada H, Sakai N et al (1990) Germ cell tumor arising in the basal ganglia in a female–case report. Neurol Med Chir (Tokyo) 30:123–126CrossRef
6.
go back to reference Calaminus G, Alapetite C, Frappaz D et al Malignant CNS germ cell tumors (GCTS): interim analysis after 5 years of SIOP CNS GCT 96 In: 39th ASCO Annual Meeting. Chicago Calaminus G, Alapetite C, Frappaz D et al Malignant CNS germ cell tumors (GCTS): interim analysis after 5 years of SIOP CNS GCT 96 In: 39th ASCO Annual Meeting. Chicago
7.
go back to reference Oyama N, Terae S, Saitoh S et al (2005) Bilateral germinoma involving the basal ganglia and cerebral white matter. AJNR Am J Neuroradiol 26:1166–1169PubMed Oyama N, Terae S, Saitoh S et al (2005) Bilateral germinoma involving the basal ganglia and cerebral white matter. AJNR Am J Neuroradiol 26:1166–1169PubMed
8.
go back to reference Garcia-Santos JM, Torres del Rio S, Sanchez A et al (2002) Basal ganglia and thalamic tumours: an imaging approximation. Childs Nerv Syst 18:412–425PubMedCrossRef Garcia-Santos JM, Torres del Rio S, Sanchez A et al (2002) Basal ganglia and thalamic tumours: an imaging approximation. Childs Nerv Syst 18:412–425PubMedCrossRef
9.
go back to reference Takeda N, Fujita K, Katayama S et al (2004) Germinoma of the basal ganglia. An 8-year asymptomatic history after detection of abnormality on CT. Pediatr Neurosurg 40:306–311PubMedCrossRef Takeda N, Fujita K, Katayama S et al (2004) Germinoma of the basal ganglia. An 8-year asymptomatic history after detection of abnormality on CT. Pediatr Neurosurg 40:306–311PubMedCrossRef
10.
go back to reference Tamaki N, Lin T, Shirataki K et al (1990) Germ cell tumors of the thalamus and the basal ganglia. Childs Nerv Syst 6:3–7PubMedCrossRef Tamaki N, Lin T, Shirataki K et al (1990) Germ cell tumors of the thalamus and the basal ganglia. Childs Nerv Syst 6:3–7PubMedCrossRef
11.
go back to reference Fujimaki T, Matsutani M, Funada N et al (1994) CT and MRI features of intracranial germ cell tumors. J Neurooncol 19:217–226PubMedCrossRef Fujimaki T, Matsutani M, Funada N et al (1994) CT and MRI features of intracranial germ cell tumors. J Neurooncol 19:217–226PubMedCrossRef
12.
go back to reference Moon WK, Chang KH, Kim IO et al (1994) Germinomas of the basal ganglia and thalamus: MR findings and a comparison between MR and CT. AJR Am J Roentgenol 162:1413–1417PubMed Moon WK, Chang KH, Kim IO et al (1994) Germinomas of the basal ganglia and thalamus: MR findings and a comparison between MR and CT. AJR Am J Roentgenol 162:1413–1417PubMed
13.
go back to reference Wong LW, Jayakumar CR (1997) Germinoma of the basal ganglia and thalamus–CT and MRI findings. Singapore Med J 38:444–446PubMed Wong LW, Jayakumar CR (1997) Germinoma of the basal ganglia and thalamus–CT and MRI findings. Singapore Med J 38:444–446PubMed
14.
go back to reference Okamoto K, Ito J, Ishikawa K et al (2002) Atrophy of the basal ganglia as the initial diagnostic sign of germinoma in the basal ganglia. Neuroradiology 44:389–394PubMedCrossRef Okamoto K, Ito J, Ishikawa K et al (2002) Atrophy of the basal ganglia as the initial diagnostic sign of germinoma in the basal ganglia. Neuroradiology 44:389–394PubMedCrossRef
15.
go back to reference Rossi A, Garre ML, Ravegnani M et al (2006) Bilateral germinoma of the basal ganglia. Pediatr Blood Cancer. doi: 1002/pbc.20905 Rossi A, Garre ML, Ravegnani M et al (2006) Bilateral germinoma of the basal ganglia. Pediatr Blood Cancer. doi: 1002/​pbc.​20905
16.
go back to reference Okamoto K, Ito J, Ishikawa K et al (2000) Diffusion-weighted echo-planar MR imaging in differential diagnosis of brain tumors and tumor-like conditions. Eur Radiol 10(8):1342–1350PubMedCrossRef Okamoto K, Ito J, Ishikawa K et al (2000) Diffusion-weighted echo-planar MR imaging in differential diagnosis of brain tumors and tumor-like conditions. Eur Radiol 10(8):1342–1350PubMedCrossRef
17.
go back to reference Kim CH, Paek SH, Park IA et al (2002) Cerebral germinoma with hemiatrophy of the brain: report of three cases. Acta Neurochir (Wien) 144:145–150CrossRef Kim CH, Paek SH, Park IA et al (2002) Cerebral germinoma with hemiatrophy of the brain: report of three cases. Acta Neurochir (Wien) 144:145–150CrossRef
18.
go back to reference Ozelame RV, Shroff M, Wood B et al (2006) Basal ganglia germinoma in children with associated ipsilateral cerebral and brain stem hemiatrophy. Pediatr Radiol 36:325–330PubMedCrossRef Ozelame RV, Shroff M, Wood B et al (2006) Basal ganglia germinoma in children with associated ipsilateral cerebral and brain stem hemiatrophy. Pediatr Radiol 36:325–330PubMedCrossRef
19.
go back to reference Liu E, Robertson RL, du Plessis A et al (1999) Basal ganglia germinoma with progressive cerebral hemiatrophy. Pediatr Neurol 20:312–314PubMedCrossRef Liu E, Robertson RL, du Plessis A et al (1999) Basal ganglia germinoma with progressive cerebral hemiatrophy. Pediatr Neurol 20:312–314PubMedCrossRef
20.
go back to reference Panigrahy A, Krieger M, Moore K et al (2005) Preoperative MR characterization of pineal germinomas: combined diffusion weighted, diffusion tensor and MR spectroscopic imaging. Neuro Oncol (7):521 (abstract) Panigrahy A, Krieger M, Moore K et al (2005) Preoperative MR characterization of pineal germinomas: combined diffusion weighted, diffusion tensor and MR spectroscopic imaging. Neuro Oncol (7):521 (abstract)
21.
go back to reference Rushing EJ, Sandberg GD, Judkins AR et al (2006) Germinoma: unusual imaging and pathological characteristics. Report of two cases. J Neurosurg 104:143–148PubMedCrossRef Rushing EJ, Sandberg GD, Judkins AR et al (2006) Germinoma: unusual imaging and pathological characteristics. Report of two cases. J Neurosurg 104:143–148PubMedCrossRef
22.
go back to reference Huh SJ, Shin KH, Kim IH et al (1996) Radiotherapy of intracranial germinomas. Radiother Oncol 38:19–23PubMedCrossRef Huh SJ, Shin KH, Kim IH et al (1996) Radiotherapy of intracranial germinomas. Radiother Oncol 38:19–23PubMedCrossRef
23.
go back to reference Maity A, Shu HK, Janss A et al (2004) Craniospinal radiation in the treatment of biopsy-proven intracranial germinomas: twenty-five years’ experience in a single center. Int J Radiat Oncol Biol Phys 58:1165–1170PubMed Maity A, Shu HK, Janss A et al (2004) Craniospinal radiation in the treatment of biopsy-proven intracranial germinomas: twenty-five years’ experience in a single center. Int J Radiat Oncol Biol Phys 58:1165–1170PubMed
24.
go back to reference Bamberg M, Kortmann RD, Calaminus G et al (1999) Radiation therapy for intracranial germinoma: results of the German cooperative prospective trials MAKEI 83/86/89. J Clin Oncol 17:2585–2592PubMed Bamberg M, Kortmann RD, Calaminus G et al (1999) Radiation therapy for intracranial germinoma: results of the German cooperative prospective trials MAKEI 83/86/89. J Clin Oncol 17:2585–2592PubMed
25.
go back to reference Shikama N, Ogawa K, Tanaka S et al (2005) Lack of benefit of spinal irradiation in the primary treatment of intracranial germinoma: a multiinstitutional, retrospective review of 180 patients. Cancer 104:126–134PubMedCrossRef Shikama N, Ogawa K, Tanaka S et al (2005) Lack of benefit of spinal irradiation in the primary treatment of intracranial germinoma: a multiinstitutional, retrospective review of 180 patients. Cancer 104:126–134PubMedCrossRef
26.
go back to reference Haas-Kogan DA, Missett BT, Wara WM et al (2003) Radiation therapy for intracranial germ cell tumors. Int J Radiat Oncol Biol Phys 56:511–518PubMedCrossRef Haas-Kogan DA, Missett BT, Wara WM et al (2003) Radiation therapy for intracranial germ cell tumors. Int J Radiat Oncol Biol Phys 56:511–518PubMedCrossRef
27.
go back to reference Ogawa K, Shikama N, Toita T et al (2004) Long-term results of radiotherapy for intracranial germinoma: a multi-institutional retrospective review of 126 patients. Int J Radiat Oncol Biol Phys 58:705–713PubMed Ogawa K, Shikama N, Toita T et al (2004) Long-term results of radiotherapy for intracranial germinoma: a multi-institutional retrospective review of 126 patients. Int J Radiat Oncol Biol Phys 58:705–713PubMed
28.
go back to reference Rogers SJ, Mosleh-Shirazi MA, Saran FH (2005) Radiotherapy of localised intracranial germinoma: time to sever historical ties? Lancet Oncol 6:509–519PubMedCrossRef Rogers SJ, Mosleh-Shirazi MA, Saran FH (2005) Radiotherapy of localised intracranial germinoma: time to sever historical ties? Lancet Oncol 6:509–519PubMedCrossRef
29.
go back to reference Shibamoto Y, Sasai K, Oya N et al (2001) Intracranial germinoma: radiation therapy with tumor volume-based dose selection. Radiology 218:452–456PubMed Shibamoto Y, Sasai K, Oya N et al (2001) Intracranial germinoma: radiation therapy with tumor volume-based dose selection. Radiology 218:452–456PubMed
30.
go back to reference Baranzelli MC, Patte C, Bouffet E et al (1997) Nonmetastatic intracranial germinoma: the experience of the French Society of Pediatric Oncology. Cancer 80:1792–1797PubMedCrossRef Baranzelli MC, Patte C, Bouffet E et al (1997) Nonmetastatic intracranial germinoma: the experience of the French Society of Pediatric Oncology. Cancer 80:1792–1797PubMedCrossRef
31.
go back to reference Fouladi M, Grant R, Baruchel S et al (1998) Comparison of survival outcomes in patients with intracranial germinomas treated with radiation alone versus reduced-dose radiation and chemotherapy. Childs Nerv Syst 14:596–601PubMedCrossRef Fouladi M, Grant R, Baruchel S et al (1998) Comparison of survival outcomes in patients with intracranial germinomas treated with radiation alone versus reduced-dose radiation and chemotherapy. Childs Nerv Syst 14:596–601PubMedCrossRef
32.
go back to reference Kobayashi T, Kageyama N, Kida Y et al (1981) Unilateral germinomas involving the basal ganglia and thalamus. J Neurosurg 55:55–62PubMedCrossRef Kobayashi T, Kageyama N, Kida Y et al (1981) Unilateral germinomas involving the basal ganglia and thalamus. J Neurosurg 55:55–62PubMedCrossRef
33.
go back to reference Elizabeth J, Menon G, Bhattacharya RN et al (2002) Germinoma of the basal ganglia: a case report and review of literature. Neurol India 50:84–86PubMed Elizabeth J, Menon G, Bhattacharya RN et al (2002) Germinoma of the basal ganglia: a case report and review of literature. Neurol India 50:84–86PubMed
34.
go back to reference Fujita T, Yamada K, Saitoh H et al (1992) Intracranial germinoma and Down’s syndrome–case report. Neurol Med Chir (Tokyo) 32:163–165CrossRef Fujita T, Yamada K, Saitoh H et al (1992) Intracranial germinoma and Down’s syndrome–case report. Neurol Med Chir (Tokyo) 32:163–165CrossRef
35.
go back to reference Garton HJ, Walker ML, Boyer RS et al (1997) A 14-year-old male with basal ganglia tumor. Pediatr Neurosurg 26:219–224PubMedCrossRef Garton HJ, Walker ML, Boyer RS et al (1997) A 14-year-old male with basal ganglia tumor. Pediatr Neurosurg 26:219–224PubMedCrossRef
36.
go back to reference Matsumura N, Kurimoto M, Endo S et al (1998) Intracranial germinoma associated with Down’s syndrome. Report of 2 cases. Pediatr Neurosurg 29:199–202PubMedCrossRef Matsumura N, Kurimoto M, Endo S et al (1998) Intracranial germinoma associated with Down’s syndrome. Report of 2 cases. Pediatr Neurosurg 29:199–202PubMedCrossRef
37.
go back to reference Tanabe M, Mizushima M, Anno Y et al (1997) Intracranial germinoma with Down’s syndrome: a case report and review of the literature. Surg Neurol 47:28–31PubMedCrossRef Tanabe M, Mizushima M, Anno Y et al (1997) Intracranial germinoma with Down’s syndrome: a case report and review of the literature. Surg Neurol 47:28–31PubMedCrossRef
38.
go back to reference Zissiadis Y, Dutton S, Kieran M et al (2001) Stereotactic radiotherapy for pediatric intracranial germ cell tumors. Int J Radiat Oncol Biol Phys 51:108–112PubMed Zissiadis Y, Dutton S, Kieran M et al (2001) Stereotactic radiotherapy for pediatric intracranial germ cell tumors. Int J Radiat Oncol Biol Phys 51:108–112PubMed
39.
go back to reference Huh SJ, Kim IH, Ha SW et al (1992) Radiotherapy of germinomas involving the basal ganglia and thalamus. Radiother Oncol 25:213–215PubMedCrossRef Huh SJ, Kim IH, Ha SW et al (1992) Radiotherapy of germinomas involving the basal ganglia and thalamus. Radiother Oncol 25:213–215PubMedCrossRef
40.
go back to reference Nakasu Y, Takeichi T, Takayama S et al (1993) Poikilothermia in a female patient with a germinoma in the basal ganglia. Acta Neurochir (Wien) 120:190–192CrossRef Nakasu Y, Takeichi T, Takayama S et al (1993) Poikilothermia in a female patient with a germinoma in the basal ganglia. Acta Neurochir (Wien) 120:190–192CrossRef
41.
go back to reference Sugimoto K, Nakahara I, Nishikawa M (2002) Bilateral metachronous germinoma of the basal ganglia occurring long after total removal of a mature pineal teratoma: case report. Neurosurgery 50:613–616PubMedCrossRef Sugimoto K, Nakahara I, Nishikawa M (2002) Bilateral metachronous germinoma of the basal ganglia occurring long after total removal of a mature pineal teratoma: case report. Neurosurgery 50:613–616PubMedCrossRef
42.
go back to reference Aoyama H, Shirato H, Kakuto Y et al (1998) Pathologically-proven intracranial germinoma treated with radiation therapy. Radiother Oncol 47:201–205PubMedCrossRef Aoyama H, Shirato H, Kakuto Y et al (1998) Pathologically-proven intracranial germinoma treated with radiation therapy. Radiother Oncol 47:201–205PubMedCrossRef
43.
go back to reference Klein O, Voirin J, Civit T et al (2007) Germinoma located in the basal ganglia in an 8-year-old girl. Childs Nerv Syst 23:105–108PubMedCrossRef Klein O, Voirin J, Civit T et al (2007) Germinoma located in the basal ganglia in an 8-year-old girl. Childs Nerv Syst 23:105–108PubMedCrossRef
44.
go back to reference Sartori S, Laverda AM, Calderone M et al (2007) Germinoma with synchronous involvement of midline and off-midline structures associated with progressive hemiparesis and hemiatrophy in a young adult. Childs Nerv Syst 23:1341–1345PubMedCrossRef Sartori S, Laverda AM, Calderone M et al (2007) Germinoma with synchronous involvement of midline and off-midline structures associated with progressive hemiparesis and hemiatrophy in a young adult. Childs Nerv Syst 23:1341–1345PubMedCrossRef
45.
go back to reference Aoyama I, Kondo A, Ogawa H et al (1994) Germinoma in siblings: case reports. Surg Neurol 41:313–317PubMedCrossRef Aoyama I, Kondo A, Ogawa H et al (1994) Germinoma in siblings: case reports. Surg Neurol 41:313–317PubMedCrossRef
46.
go back to reference Chik K, Li C, Shing MM et al (1999) Intracranial germ cell tumors in children with and without Down syndrome. J Pediatr Hematol Oncol 21:149–151PubMedCrossRef Chik K, Li C, Shing MM et al (1999) Intracranial germ cell tumors in children with and without Down syndrome. J Pediatr Hematol Oncol 21:149–151PubMedCrossRef
47.
go back to reference Utsuki S, Oka H, Tanizaki Y et al (2006) Histological features of intracranial germinomas not disappearing immediately after radiotherapy. Neurol Med Chir (Tokyo) 46:429–433CrossRef Utsuki S, Oka H, Tanizaki Y et al (2006) Histological features of intracranial germinomas not disappearing immediately after radiotherapy. Neurol Med Chir (Tokyo) 46:429–433CrossRef
Metadata
Title
Inherent diagnostic and treatment challenges in germinoma of the basal ganglia: a case report and review of the literature
Authors
Anita Villani
Eric Bouffet
Susan Blaser
Barbara-Ann Millar
Cynthia Hawkins
Ute Bartels
Publication date
01-07-2008
Publisher
Springer US
Published in
Journal of Neuro-Oncology / Issue 3/2008
Print ISSN: 0167-594X
Electronic ISSN: 1573-7373
DOI
https://doi.org/10.1007/s11060-008-9568-7

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