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01-10-2018 | Short Communication

Influence of Thrombolysis on the Safety and Efficacy of Blocking Platelet Adhesion or Secretory Activity in Acute Ischemic Stroke in Mice

Authors: Michael K. Schuhmann, Peter Kraft, Michael Bieber, Axel Haarmann, György A. Homola, Mirko Pham, Bernhard Nieswandt, Guido Stoll

Published in: Translational Stroke Research | Issue 5/2018

Abstract

In acute ischemic stroke (AIS), there is an alarming discrepancy between recanalization rates of up to 70% by combined recombinant tissue-type plasminogen activator (rt-PA) therapy and mechanical thrombectomy, and no clinical benefit in at least every second stroke patient. This is partly due to ischemia/reperfusion (I/R) injury. In a translational approach, we used mice lacking dense- (Unc13d^−/−) or α-granules (Nbeal2^−/−) and mice after blocking of platelet glycoprotein receptor (GP) Ib conferring protection from I/R injury. These mice underwent transient middle cerebral artery occlusion (tMCAO) and, as in the clinic, were treated with rt-PA. Our data show that rt-PA treatment is still safe in conjunction with selected anti-platelet therapies and pave the way for eagerly awaited additive treatment options in acute human stroke.

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Title: Influence of Thrombolysis on the Safety and Efficacy of Blocking Platelet Adhesion or Secretory Activity in Acute Ischemic Stroke in Mice
Authors: Michael K. Schuhmann
Peter Kraft
Michael Bieber
Axel Haarmann
György A. Homola
Mirko Pham
Bernhard Nieswandt
Guido Stoll
Publication date: 01-10-2018
Publisher: Springer US
Published in: Translational Stroke Research / Issue 5/2018
Print ISSN: 1868-4483
Electronic ISSN: 1868-601X
DOI: https://doi.org/10.1007/s12975-017-0606-7

At a glance: The STEP trials

Springer Medicine

Influence of Thrombolysis on the Safety and Efficacy of Blocking Platelet Adhesion or Secretory Activity in Acute Ischemic Stroke in Mice

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

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