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Archives of Women's Mental Health

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01-10-2016 | Original Article

Influence of prenatal maternal stress on umbilical cord blood cytokine levels

Authors: Niklas W. Andersson, Qian Li, Carrie W. Mills, Jenny Ly, Yoko Nomura, Jia Chen

Published in: Archives of Women's Mental Health | Issue 5/2016

Abstract

Purpose

Prenatal maternal stress (PNMS) is known to influence fetal programming and development. Thus far, the effects of PNMS on the developing immune system have mainly been documented in animal studies. This study aimed to examine the association between PNMS and immune cytokine profiles in the umbilical cord blood of newborn human infants.

Methods

PNMS, including perceived stress, numbers of stressful life events experiences (both partner and health related), and state and trait anxiety, was assessed with five questionnaires and interviews from 43 pregnant women during the second trimester. Seven key cytokines important for immune function, i.e., IL-12, IL-1β, IL-4, IL-5, IL-6, IL-8, and TNF-α, were analyzed in cord blood by bead-based ELISA method (Luminex 200). Logistic regression was used to estimate the associations of PNMS scores and cytokine levels.

Results

Increased levels of IL-1β, IL-4, IL-5, IL-6, and IL-8 were significantly associated with at least one of the maternal stress assessments, while the levels of IL-12 and TNF-α were not significantly associated with any of the PNMS measurements examined.

Conclusion

These preliminary findings suggest that PNMS may influence cytokine levels in newborn infants, in particular Th2-related cytokines. This report supports previous findings in animal studies and could suggest that newborns born to mothers with elevated PNMS have a predisposition to immune-related disorders.

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Title: Influence of prenatal maternal stress on umbilical cord blood cytokine levels
Authors: Niklas W. Andersson
Qian Li
Carrie W. Mills
Jenny Ly
Yoko Nomura
Jia Chen
Publication date: 01-10-2016
Publisher: Springer Vienna
Published in: Archives of Women's Mental Health / Issue 5/2016
Print ISSN: 1434-1816
Electronic ISSN: 1435-1102
DOI: https://doi.org/10.1007/s00737-016-0607-7

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Influence of prenatal maternal stress on umbilical cord blood cytokine levels

Abstract

Purpose

Methods

Results

Conclusion

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusion

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