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01-01-2013 | Original Article

Influence of MMP-8 promoter polymorphism in early osseointegrated implant failure

Authors: F. R. Costa-Junior, C. C. Alvim-Pereira, F. Alvim-Pereira, P. C. Trevilatto, A. P. de Souza, Maria Cristina L. G. Santos

Published in: Clinical Oral Investigations | Issue 1/2013

Abstract

Objective

Dental implants consist in the treatment of choice to replace tooth loss. The knowledge that implant loss tends to cluster in subsets of individuals may indicate that host immuneinflammatory response is influenced by genetic factors. In fact, genetic polymorphisms influence the osseointegration process. The objective of this study was investigate the possible relationship between C-799T polymorphism in matrix metalloproteinase 8 (MMP-8) gene and early implant failure in nonsmoker patients.

Methods and materials

Subjects were divided into two groups: control group (100 patients with one or more healthy implants) and test group (80 patients that had suffered one or more early implant failures). Genomic DNA from oral mucosa was amplified by PCR and analyzed by restriction endonucleases. The significance of the differences in observed frequencies of polymorphisms was assessed by Chi-square.

Results

Statistical analysis shows that in the MMP-8 gene, the T allele in 76.25% in the test group and the T/T genotype, 63.75% in the same group, may predispose to early loss of implants osseointegrated.

Conclusion

These results suggest that polymorphism in the promoter region of MMP-8 gene is associated with early implant failure. This polymorphism can be a genetic marker to risk of implant loss.

Clinical relevance

The determination of this genetic pattern in osseointegration would enable the identification of individuals at higher risk to loss implant. Thus, genetic markers will be identified, contributing to an appropriate preoperative selection and preparation of strategies for prevention and therapy individualized to modulate the genetic markers and increase the success rate of treatments.

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Title: Influence of MMP-8 promoter polymorphism in early osseointegrated implant failure
Authors: F. R. Costa-Junior
C. C. Alvim-Pereira
F. Alvim-Pereira
P. C. Trevilatto
A. P. de Souza
Maria Cristina L. G. Santos
Publication date: 01-01-2013
Publisher: Springer-Verlag
Published in: Clinical Oral Investigations / Issue 1/2013
Print ISSN: 1432-6981
Electronic ISSN: 1436-3771
DOI: https://doi.org/10.1007/s00784-012-0699-z

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Influence of MMP-8 promoter polymorphism in early osseointegrated implant failure

Abstract

Objective

Methods and materials

Results

Conclusion

Clinical relevance

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Objective

Methods and materials

Results

Conclusion

Clinical relevance

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