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01-03-2008 | Cardiac

Influence of intra-coronary enhancement on diagnostic accuracy with 64-slice CT coronary angiography

Authors: Filippo Cademartiri, Erica Maffei, Anselmo Alessandro Palumbo, Roberto Malagò, Ludovico La Grutta, W. Bob Meiijboom, Annachiara Aldrovandi, Michele Fusaro, Luigi Vignali, Alberto Menozzi, Valerio Brambilla, Paolo Coruzzi, Massimo Midiri, Miles A. Kirchin, Nico R. A. Mollet, Gabriel P. Krestin

Published in: European Radiology | Issue 3/2008

Abstract

We assessed the effect of intra-coronary attenuation on diagnostic accuracy using 64-slice computed tomography coronary angiography (CT-CA). We enrolled 170 patients with suspected coronary artery disease who underwent conventional coronary angiography (CA) and 64-slice CT-CA (100 ml of Iomeprol 400 mg I/ml at 4 ml/s). The study population was divided into two groups (85 patients each based on median attenuation of 326 HU) based on mean arterial attenuation; group 1 with low attenuation and group 2 with high attenuation. Diagnostic accuracy for the detection of significant coronary artery stenosis was determined for both groups using CA as reference standard. Overall, 163 significant stenoses were detected in 1,030 assessable coronary artery segments in group 1 compared with 160 significant stenoses in 1,020 assessable segments in group 2. The average intra-coronary attenuation was significantly (P < 0.05) higher for group 2 (388 ± 46 HU) compared with group 1 (291 ± 33 HU). The corresponding sensitivity and specificity values for detection of significant coronary artery stenosis were higher for group 2 (96.3% and 97.6%, respectively) than for group 1 (82.8% and 93.2%, respectively) and were more marked in distal coronary segments than in proximal segments. Higher intra-coronary attenuation on CT-CA results in greater diagnostic accuracy for detection of coronary artery stenosis.

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Title: Influence of intra-coronary enhancement on diagnostic accuracy with 64-slice CT coronary angiography
Authors: Filippo Cademartiri
Erica Maffei
Anselmo Alessandro Palumbo
Roberto Malagò
Ludovico La Grutta
W. Bob Meiijboom
Annachiara Aldrovandi
Michele Fusaro
Luigi Vignali
Alberto Menozzi
Valerio Brambilla
Paolo Coruzzi
Massimo Midiri
Miles A. Kirchin
Nico R. A. Mollet
Gabriel P. Krestin
Publication date: 01-03-2008
Publisher: Springer-Verlag
Published in: European Radiology / Issue 3/2008
Print ISSN: 0938-7994
Electronic ISSN: 1432-1084
DOI: https://doi.org/10.1007/s00330-007-0773-0

At a glance: The STEP trials

Springer Medicine

Influence of intra-coronary enhancement on diagnostic accuracy with 64-slice CT coronary angiography

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

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Acknowledgement to reviewers