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Molecular Imaging and Biology
Published in: Molecular Imaging and Biology 2/2011

01-04-2011 | Research Article

Influence of Glioma's Multidrug Resistance Phenotype on 99mTc-Tetrofosmin Uptake

Authors: George A. Alexiou, Anna Goussia, Athanasios P. Kyritsis, Spyridon Tsiouris, Antigoni Ntoulia, Vassiliki Malamou-Mitsi, Spyridon Voulgaris, Andreas D. Fotopoulos

Published in: Molecular Imaging and Biology | Issue 2/2011

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Abstract

Purpose

Multidrug resistance (MDR) remains a major obstacle to successful chemotherapeutic treatment of cancer. Several chemotherapeutic and radiopharmaceutical agents are substrates of the pumps encoded by the MDR genes, and therefore, their accumulation is prevented. We evaluated in vivo whether [99mTc]tetrofosmin (99mTc-TF) uptake is influenced by the MDR profile of gliomas.

Procedures

Eighteen patients with histologically confirmed glioma were included in the study. Brain single-photon emission computed tomography by 99mTc-TF was performed within a week prior to surgical excision, and the expression of MRP5 was assessed by immunohistochemistry. Radiotracer accumulation was assessed by a semiquantitative method, calculating the lesion-to-normal uptake ratio.

Results

Using Spearman's ρ analysis, we found no correlation between tracer uptake expressed as lesion-to-normal and MRP5 expression. There was a significant correlation between glioma aggressiveness as assessed by Ki-67/MIB-1 and MRP5 expression.

Conclusion

The present data suggest that 99mTc-TF uptake is not influenced by glioma's MDR phenotype. Thus, 99mTc-TF constitutes a suitable radiotracer for imaging gliomas.
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Metadata
Title
Influence of Glioma's Multidrug Resistance Phenotype on 99mTc-Tetrofosmin Uptake
Authors
George A. Alexiou
Anna Goussia
Athanasios P. Kyritsis
Spyridon Tsiouris
Antigoni Ntoulia
Vassiliki Malamou-Mitsi
Spyridon Voulgaris
Andreas D. Fotopoulos
Publication date
01-04-2011
Publisher
Springer-Verlag
Published in
Molecular Imaging and Biology / Issue 2/2011
Print ISSN: 1536-1632
Electronic ISSN: 1860-2002
DOI
https://doi.org/10.1007/s11307-010-0369-y

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