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European Journal of Applied Physiology

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01-10-2016 | Original Article

Influence of chronic endurance exercise training on conduit artery retrograde and oscillatory shear in older adults

Authors: Darren P. Casey, Aaron C. Schneider, Kenichi Ueda

Published in: European Journal of Applied Physiology | Issue 10/2016

Abstract

Purpose

With aging, there tends to be an increase in retrograde and oscillatory shear in peripheral conduit arteries of humans. Whether the increase in shear rate is due to the aging process or an effect of a less active lifestyle that often accompanies aging is unknown. Therefore, we examined whether chronic endurance exercise training attenuates conduit artery retrograde and oscillatory shear in older adults.

Methods

Brachial and common femoral artery mean blood velocities and diameter were determined via Doppler ultrasound under resting conditions, and shear rate was calculated in 13 young (24 ± 2 years), 17 older untrained (66 ± 3 years), and 16 older endurance exercise-trained adults (66 ± 7 years).

Results

Brachial artery retrograde (−9.1 ± 6.4 vs. −12.6 ± 9.4 s⁻¹; P = 0.35) and oscillatory (0.14 ± 0.08 vs. 0.14 ± 0.08 arbitrary units; P = 0.99) shear were similar between the older trained and untrained groups, whereas brachial artery retrograde and oscillatory shear were greater in older untrained compared to young adults (−5.0 ± 3.4, 0.08 ± 0.05 s⁻¹ arbitrary units, P = 0.017 and 0.048, respectively). There was no difference between the young and older trained brachial retrograde (P = 0.29) and oscillatory (P = 0.07) shear. Common femoral artery retrograde (−6.3 ± 2.9 s⁻¹) and oscillatory (0.21 ± 0.08 arbitrary units) shear were reduced in older trained compared to the older untrained group (−10.4 ± 4.1 and 0.30 ± 0.09 s⁻¹ arbitrary units, both P = 0.005 and 0.006, respectively), yet similar to young adults (−7.1 ± 3.5 and 0.19 ± 0.06 s⁻¹ arbitrary units, P = 0.81 and 0.87, respectively).

Conclusion

Our results suggest that chronic endurance exercise training in older adults ameliorates retrograde and oscillatory shear rate patterns, particularly in the common femoral artery.

Akazawa N, Choi Y, Miyaki A, Tanabe Y, Sugawara J, Ajisaka R, Maeda S (2012) Curcumin ingestion and exercise training improve vascular endothelial function in postmenopausal women. Nutr Res 32(10):795–799. doi:10.1016/j.nutres.2012.09.002 CrossRefPubMed

Blackshear WM Jr, Phillips DJ, Strandness DE Jr (1979) Pulsed Doppler assessment of normal human femoral artery velocity patterns. J Surg Res 27(2):73–83CrossRefPubMed

Blair SN, Morris JN (2009) Healthy hearts-and the universal benefits of being physically active: physical activity and health. Ann Epidemiol 19(4):253–256. doi:10.1016/j.annepidem.2009.01.019 CrossRefPubMed

Casey DP, Padilla J, Joyner MJ (2012) Alpha-adrenergic vasoconstriction contributes to the age-related increase in conduit artery retrograde and oscillatory shear. Hypertension 60(4):1016–1022. doi:10.1161/HYPERTENSIONAHA.112.200618 CrossRefPubMedPubMedCentral

Celermajer DS, Sorensen KE, Spiegelhalter DJ, Georgakopoulos D, Robinson J, Deanfield JE (1994) Aging is associated with endothelial dysfunction in healthy men years before the age-related decline in women. J Am Coll Cardiol 24(2):471–476CrossRefPubMed

Chien S (2008) Effects of disturbed flow on endothelial cells. Ann Biomed Eng 36(4):554–562. doi:10.1007/s10439-007-9426-3 CrossRefPubMedPubMedCentral

Conway DE, Williams MR, Eskin SG, McIntire LV (2010) Endothelial cell responses to atheroprone flow are driven by two separate flow components: low time-average shear stress and fluid flow reversal. Am J Physiol Heart Circ Physiol 298(2):H367–H374. doi:10.1152/ajpheart.00565.2009 CrossRefPubMed

DeSouza CA, Shapiro LF, Clevenger CM, Dinenno FA, Monahan KD, Tanaka H, Seals DR (2000) Regular aerobic exercise prevents and restores age-related declines in endothelium-dependent vasodilation in healthy men. Circulation 102(12):1351–1357CrossRefPubMed

Donato AJ, Lesniewski LA, Delp MD (2007) Ageing and exercise training alter adrenergic vasomotor responses of rat skeletal muscle arterioles. J Physiol 579(Pt 1):115–125. doi:10.1113/jphysiol.2006.120055 CrossRefPubMed

Eskurza I, Myerburgh LA, Kahn ZD, Seals DR (2005) Tetrahydrobiopterin augments endothelium-dependent dilatation in sedentary but not in habitually exercising older adults. J Physiol 568(Pt 3):1057–1065. doi:10.1113/jphysiol.2005.092734 CrossRefPubMedPubMedCentral

Fielding RA, Frontera WR, Hughes VA, Fisher EC, Evans WJ (1997) The reproducibility of the Bruce protocol exercise test for the determination of aerobic capacity in older women. Med Sci Sports Exerc 29(8):1109–1113CrossRefPubMed

Gerhard M, Roddy MA, Creager SJ, Creager MA (1996) Aging progressively impairs endothelium-dependent vasodilation in forearm resistance vessels of humans. Hypertension 27(4):849–853CrossRefPubMed

Hahn C, Schwartz MA (2009) Mechanotransduction in vascular physiology and atherogenesis. Nat Rev Mol Cell Biol 10(1):53–62. doi:10.1038/nrm2596 CrossRefPubMedPubMedCentral

Herr MD, Hogeman CS, Koch DW, Krishnan A, Momen A, Leuenberger UA (2010) A real-time device for converting Doppler ultrasound audio signals into fluid flow velocity. Am J Physiol Heart Circ Physiol 298(5):H1626–H1632. doi:10.1152/ajpheart.00713.2009 CrossRefPubMedPubMedCentral

Hughes WE, Ueda K, Casey DP (2016) Chronic endurance exercise training offsets the age-related attenuation in contraction-induced rapid vasodilation. J Appl Physiol 120(11):1335–1142. doi:10.1152/japplphysiol.00057.2016 CrossRefPubMed

Johnson BD, Mather KJ, Newcomer SC, Mickleborough TD, Wallace JP (2013) Vitamin C prevents the acute decline of flow-mediated dilation after altered shear rate patterns. Physiologie appliquee nutrition et metabolisme 38(3):268–274. doi:10.1139/apnm-2012-0169 CrossRef

Kroger K, Kucharczik A, Hirche H, Rudofsky G (1999) Atherosclerotic lesions are more frequent in femoral arteries than in carotid arteries independent of increasing number of risk factors. Angiology 50(8):649–654CrossRefPubMed

Ku DN, Giddens DP, Zarins CK, Glagov S (1985) Pulsatile flow and atherosclerosis in the human carotid bifurcation. Positive correlation between plaque location and low oscillating shear stress. Arteriosclerosis 5(3):293–302CrossRefPubMed

Laughlin MH, Newcomer SC, Bender SB (2008) Importance of hemodynamic forces as signals for exercise-induced changes in endothelial cell phenotype. J Appl Physiol 104(3):588–600. doi:10.1152/japplphysiol.01096.2007 CrossRefPubMed

Lu X, Kassab GS (2004) Nitric oxide is significantly reduced in ex vivo porcine arteries during reverse flow because of increased superoxide production. J Physiol 561(Pt 2):575–582. doi:10.1113/jphysiol.2004.075218 CrossRefPubMedPubMedCentral

Minson CT, Halliwill JR, Young TM, Joyner MJ (2000) Influence of the menstrual cycle on sympathetic activity, baroreflex sensitivity, and vascular transduction in young women. Circulation 101(8):862–868CrossRefPubMed

Newcomer SC, Sauder CL, Kuipers NT, Laughlin MH, Ray CA (2008) Effects of posture on shear rates in human brachial and superficial femoral arteries. Am J Physiol Heart Circ Physiol 294(4):H1833–H1839. doi:10.1152/ajpheart.01108.2007 CrossRefPubMedPubMedCentral

Nyberg M, Blackwell JR, Damsgaard R, Jones AM, Hellsten Y, Mortensen SP (2012) Lifelong physical activity prevents an age-related reduction in arterial and skeletal muscle nitric oxide bioavailability in humans. J Physiol 590(Pt 21):5361–5370. doi:10.1113/jphysiol.2012.239053 CrossRefPubMedPubMedCentral

Padilla J, Sheldon RD, Sitar DM, Newcomer SC (2009) Impact of acute exposure to increased hydrostatic pressure and reduced shear rate on conduit artery endothelial function: a limb-specific response. Am J Physiol Heart Circ Physiol 297(3):H1103–H1108. doi:10.1152/ajpheart.00167.2009 CrossRefPubMed

Padilla J, Young CN, Simmons GH, Deo SH, Newcomer SC, Sullivan JP, Laughlin MH, Fadel PJ (2010) Increased muscle sympathetic nerve activity acutely alters conduit artery shear rate patterns. Am J Physiol Heart Circ Physiol 298(4):H1128–H1135. doi:10.1152/ajpheart.01133.2009 CrossRefPubMedPubMedCentral

Padilla J, Simmons GH, Bender SB, Arce-Esquivel AA, Whyte JJ, Laughlin MH (2011a) Vascular effects of exercise: endothelial adaptations beyond active muscle beds. Physiology 26(3):132–145. doi:10.1152/physiol.00052.2010 CrossRefPubMedPubMedCentral

Padilla J, Simmons GH, Fadel PJ, Laughlin MH, Joyner MJ, Casey DP (2011b) Impact of aging on conduit artery retrograde and oscillatory shear at rest and during exercise: role of nitric oxide. Hypertension 57(3):484–489. doi:10.1161/HYPERTENSIONAHA.110.165365 CrossRefPubMedPubMedCentral

Pierce GL, Donato AJ, LaRocca TJ, Eskurza I, Silver AE, Seals DR (2011a) Habitually exercising older men do not demonstrate age-associated vascular endothelial oxidative stress. Aging Cell 10(6):1032–1037. doi:10.1111/j.1474-9726.2011.00748.x CrossRefPubMedPubMedCentral

Pierce GL, Eskurza I, Walker AE, Fay TN, Seals DR (2011b) Sex-specific effects of habitual aerobic exercise on brachial artery flow-mediated dilation in middle-aged and older adults. Clin Sci 120(1):13–23. doi:10.1042/CS20100174 CrossRefPubMed

Schreuder TH, Green DJ, Hopman MT, Thijssen DH (2014) Acute impact of retrograde shear rate on brachial and superficial femoral artery flow-mediated dilation in humans. Physiol Rep 2(1):e00193. doi:10.1002/phy2.193 CrossRefPubMedPubMedCentral

Seals DR, Desouza CA, Donato AJ, Tanaka H (2008) Habitual exercise and arterial aging. J Appl Physiol 105(4):1323–1332. doi:10.1152/japplphysiol.90553.2008 CrossRefPubMedPubMedCentral

Seals DR, Kaplon RE, Gioscia-Ryan RA, LaRocca TJ (2014) You’re only as old as your arteries: translational strategies for preserving vascular endothelial function with aging. Physiology 29(4):250–264. doi:10.1152/physiol.00059.2013 CrossRefPubMedPubMedCentral

Stary HC, Chandler AB, Dinsmore RE, Fuster V, Glagov S, Insull W Jr, Rosenfeld ME, Schwartz CJ, Wagner WD, Wissler RW (1995) A definition of advanced types of atherosclerotic lesions and a histological classification of atherosclerosis. A report from the Committee on Vascular Lesions of the Council on Arteriosclerosis, American Heart Association. Circulation 92(5):1355–1374CrossRefPubMed

Taddei S, Virdis A, Mattei P, Ghiadoni L, Gennari A, Fasolo CB, Sudano I, Salvetti A (1995) Aging and endothelial function in normotensive subjects and patients with essential hypertension. Circulation 91(7):1981–1987CrossRefPubMed

Taddei S, Galetta F, Virdis A, Ghiadoni L, Salvetti G, Franzoni F, Giusti C, Salvetti A (2000) Physical activity prevents age-related impairment in nitric oxide availability in elderly athletes. Circulation 101(25):2896–2901CrossRefPubMed

Thijssen DH, Dawson EA, Tinken TM, Cable NT, Green DJ (2009) Retrograde flow and shear rate acutely impair endothelial function in humans. Hypertension 53(6):986–992. doi:10.1161/HYPERTENSIONAHA.109.131508 CrossRefPubMed

Thijssen DH, Schreuder TH, Newcomer SW, Laughlin MH, Hopman MT, Green DJ (2015) Impact of 2-weeks continuous increase in retrograde shear stress on brachial artery vasomotor function in young and older men. J Am Heart Assoc. doi:10.1161/JAHA.115.001968 PubMedPubMedCentral

Tinken TM, Thijssen DH, Hopkins N, Black MA, Dawson EA, Minson CT, Newcomer SC, Laughlin MH, Cable NT, Green DJ (2009) Impact of shear rate modulation on vascular function in humans. Hypertension 54(2):278–285. doi:10.1161/HYPERTENSIONAHA.109.134361 CrossRefPubMedPubMedCentral

Totosy de Zepetnek JO, Jermey TL, MacDonald MJ (2014) Superficial femoral artery endothelial responses to a short-term altered shear rate intervention in healthy men. PLoS One 9(11):e113407. doi:10.1371/journal.pone.0113407 CrossRefPubMedPubMedCentral

Trinity JD, Groot HJ, Layec G, Rossman MJ, Ives SJ, Richardson RS (2014) Impact of age and body position on the contribution of nitric oxide to femoral artery shear rate: implications for atherosclerosis. Hypertension 63(5):1019–1025. doi:10.1161/HYPERTENSIONAHA.113.02854 CrossRefPubMedPubMedCentral

Wang C, Baker BM, Chen CS, Schwartz MA (2013) Endothelial cell sensing of flow direction. Arterioscler Thromb Vasc Biol 33(9):2130–2136. doi:10.1161/ATVBAHA.113.301826 CrossRefPubMed

Wray DW, Uberoi A, Lawrenson L, Richardson RS (2006) Evidence of preserved endothelial function and vascular plasticity with age. Am J Physiol Heart Circ Physiol 290(3):H1271–H1277. doi:10.1152/ajpheart.00883.2005 CrossRefPubMed

Wu SP, Ringgaard S, Oyre S, Hansen MS, Rasmus S, Pedersen EM (2004) Wall shear rates differ between the normal carotid, femoral, and brachial arteries: an in vivo MRI study. J Magn Reson Imaging JMRI 19(2):188–193. doi:10.1002/jmri.10441 CrossRefPubMed

Yoshizawa M, Maeda S, Miyaki A, Misono M, Choi Y, Shimojo N, Ajisaka R, Tanaka H (2010) Additive beneficial effects of lactotripeptides intake with regular exercise on endothelium-dependent dilatation in postmenopausal women. Am J Hypertens 23(4):368–372. doi:10.1038/ajh.2009.270 CrossRefPubMed

Young CN, Deo SH, Padilla J, Laughlin MH, Fadel PJ (2010) Pro-atherogenic shear rate patterns in the femoral artery of healthy older adults. Atherosclerosis 211(2):390–392. doi:10.1016/j.atherosclerosis.2010.03.017 CrossRefPubMedPubMedCentral

Title: Influence of chronic endurance exercise training on conduit artery retrograde and oscillatory shear in older adults
Authors: Darren P. Casey
Aaron C. Schneider
Kenichi Ueda
Publication date: 01-10-2016
Publisher: Springer Berlin Heidelberg
Published in: European Journal of Applied Physiology / Issue 10/2016
Print ISSN: 1439-6319
Electronic ISSN: 1439-6327
DOI: https://doi.org/10.1007/s00421-016-3445-4

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Influence of chronic endurance exercise training on conduit artery retrograde and oscillatory shear in older adults

Abstract

Purpose

Methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusion

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