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Surgical Endoscopy

Published in:

01-02-2010

Influence of a new self-gripping hernia mesh on male fertility in a rat model

Authors: Thomas Kolbe, Christian Hollinsky, Ingrid Walter, Anja Joachim, Thomas Rülicke

Published in: Surgical Endoscopy | Issue 2/2010

Abstract

Background

The number of mesh-based therapies of inguinal hernias is increasing compared with the classical suture techniques such as Shouldice and Bassini. Many different types of meshes with regard to material, pore size and surface coating are available. A recently offered mesh (Parietene™ Progrip™) combines the properties of a standard lightweight polypropylene mesh with a whole surface fixation by incorporation of micro hooks. Therefore, additional fixation elements such as screws, tacks or clips become redundant when using this material. However, in treated male patients the micro hooks will also come into contact with the ductus deferens. As the sensitivity of this structure is known, the question arises of whether this new self-gripping mesh might damage susceptible tissue layers and impair male fertility.

Methods

Two different meshes, a standard lightweight polypropylene mesh (Parietene-Light™) and a new self-gripping polypropylene mesh (Parietene™ Progrip™) with absorbable micro hooks were wrapped surgically around the prepared ductus deferens of each of ten Sprague–Dawley rats. In five control rats ducts were only separated bluntly from adherent tissue. After 2 months rats were sacrificed and implants were recovered together with the ductus deferens for histology and electron microscopy.

Results

Samples from all animals showed an unrestricted lumen of the ductus deferens. Only minor inflammatory reactions with some infiltrating cells could be observed. Giant cells were present around the mesh fibres. Scanning electron microscopy revealed no degradation of the material surface after 2 months of implantation.

Conclusion

The new self-gripping mesh showed no harmful influence on the ductus deferens in the rat model. Considering the larger dimensions of the ductus deferens in humans any detrimental effect on the exposed tissue can be excluded. The surface of the fibres was not subjected to material degradation.

Nathan JD, Pappas TN (2003) Inguinal hernia: an old condition with new solutions. Ann Surg 238:148–157

Barrat C, Seriser F, Arnoud R, Trouette P, Champault G (2004) Inguinal hernia repair with beta glucan-coated mesh: prospective multicenter study (115 cases)—preliminary results. Hernia 8:33–38CrossRefPubMed

Junge K, Rosch R, Klinge U, Saklak M, Klosterhalfen B, Peiper C, Schumpelick V (2005) Titanium coating of a polypropylene mesh for hernia repair: effect on biocompatibility. Hernia 9:115–119CrossRefPubMed

Junge K, Rosch R, Krones CJ, Klinge U, Mertens PR, Lynen P et al (2005) Influence of polyglecaprone 25 (Monocryl) suppelmentation on the biocompatibility of a polypropylene mesh for hernia repair. Hernia 9:212–217CrossRefPubMed

Sandhu DP, Osborn DE (1991) Surgical technique for inguinal surgery and its effect on fertility in the Wistar rat model. Br J Urol 68:513–517CrossRefPubMed

Silich RC, McSherry CK (1996) Spermatic granuloma. An uncommon complication of the tension-free hernia repair. Surg Endosc 10:537–539CrossRefPubMed

Hetzer FH, Hotz T, Steinke W, Schlumpf R, Decurtins M, Largiader F (1999) Gold standard for inguinal hernia repair: Shouldice or Lichtenstein ? Hernia 3:117–120CrossRef

Close B, Banister K, Baumans V, Bernoth E-M, Bromage N, Bunyan J et al (1996) Recommendations for euthanasia of experimental animals: part 1. Lab Anim 30:293–316CrossRefPubMed

Close B, Banister K, Baumans V, Bernoth E-M, Bromage N, Bunyan J, Erhardt W et al (1997) Recommendations for euthanasia of experimental animals: part 2. Lab Anim 31:1–32CrossRefPubMed

10.

Shandling B, Janik JS (1981) The vulnerability of the vas deferens. J Ped Surg 16:461–464CrossRef

11.

Yavetz H, Harash B, Yogev L, Homonnai ZT, Paz G (1991) Fertility of men following inguinal hernia repair. Andrologia 23:443–446PubMedCrossRef

12.

Shin D, Lipshultz LI, Goldstein M, Barme GA, Fuchs EF, Nagler HM et al (2005) Herniorrhaphy with polypropylene mesh causing inguinal vasal obstruction. Ann Surg 241:553–558CrossRefPubMed

13.

Uzzo RG, Lemack GE, Morrissey KP, Goldstein M (1999) The effects of mesh bioprosthesis on the spermatic cord structures: a preliminary report in a canine model. J Urol 161:1344–1349CrossRefPubMed

14.

Goldenberg A, Paula JF (2005) Effects of the polypropylene mesh implanted through inguinotomy in the spermatic funiculus, epididium and testis of dogs. Acta Cir Bras 20:461–467PubMed

15.

Peiper C, Junge K, Klinge U, Strehlau E, Krones C, Ottinger A et al (2005) The influence of inguinal mesh repair on the spermatic cord: a pilot study in the rabbit. J Invest Surg 18:273–278CrossRefPubMed

16.

Peiper C, Junge K, Klinge U, Strehlau E, Ottinger A, Schumpelick V (2006) Is there a risk of infertility after inguinal mesh repair? Experimental studies in the pig and the rabbit. Hernia 10:7–12CrossRefPubMed

17.

Smith EM, Dahms BB, Elder JS (1993) Influence of vas deferens mobilization on rat fertility: implications regarding orchidopexy. J Urol 150:663–666PubMed

18.

Abasiyanik A, Guvenc H, Yavuzer D, Peker O, Ince U (1997) The effect of iatrogenic vas deferens injury on fertility in an experimental rat model. J Pediatr Surg 32:1144–1146CrossRefPubMed

19.

Berndsen FH, Bjursten LM, Simanaitis M, Montgomery A (2004) Does mesh implantation affect the spermatic cord structures after inguinal hernia surgery? An experimental study in rats. Eur Surg Res 36:318–322CrossRefPubMed

20.

Taneli F, Aydede H, Vatansever S, Ulman C, Ari Z, Uyanik BS (2005) The long-term effect of mesh bioprosthesis in inguinal hernia repair on testicular nitric oxide metabolism and apoptosis in rat testis. Cell Biochem Funct 23:213–220CrossRefPubMed

21.

Kolbe T, Lechner W (2007) Influence of hernioplastic implants on male fertility in rats. J Biomed Mater Res B 81B:435–440CrossRef

22.

Klinge U, Klosterhalfen B, Müller M, Schumpelick V (1999) Foreign body reaction to meshes used fort he repair of abdominal wall hernias. Eur J Surg 165:665–673CrossRefPubMed

23.

Klosterhalfen B, Klinge U, Hermanns B, Schumpelick V (2000) Pathology of traditional surgical nets for hernia repair after long-term implantation in humans. Chirurg 71:43–51PubMed

24.

Klosterhalfen B, Klinge U, Schumpelick V (1998) Functional and morphological evaluation of different polypropylene-mesh modifications for abdominal wall repair. Biomaterials 19:2235–2246CrossRefPubMed

25.

Hagerty RD, Salzmann DL, Kleinert LB, Williams SK (2000) Cellular proliferation and macrophage populations associated with implanted expanded polytetrafluoroethylene and polyethyleneterephthalate. J Biomed Mater Res 49:489–497CrossRefPubMed

26.

Rosch R, Junge K, Schachtrupp A, Klinge U, Klosterhalfen B, Schumpelick V (2003) Mesh implants in hernia repair. Inflammatory cell response in a rat model. Eur Surg Res 35:161–166CrossRefPubMed

27.

Goldenberg A, Matone J, Marcondes W, Herbella FW, Farah JF (2005) Comparative study of inflammatory response and adhesions formation after wffixation of different meshes for inguinal hernia repair in rabbits. Acta Cir Bras 20:347–352PubMed

28.

Junge K, Klinge U, Rosch R, Klosterhalfen B, Schumpelick V (2002) Functional and morphologic properties of a modified mesh for inguinal hernia repair. World J Surg 26:1472–1780CrossRefPubMed

Title: Influence of a new self-gripping hernia mesh on male fertility in a rat model
Authors: Thomas Kolbe
Christian Hollinsky
Ingrid Walter
Anja Joachim
Thomas Rülicke
Publication date: 01-02-2010
Publisher: Springer-Verlag
Published in: Surgical Endoscopy / Issue 2/2010
Print ISSN: 0930-2794
Electronic ISSN: 1432-2218
DOI: https://doi.org/10.1007/s00464-009-0596-y

2024 ASCO Annual Meeting

Springer Medicine

Influence of a new self-gripping hernia mesh on male fertility in a rat model

Abstract

Background

Methods

Results

Conclusion

2024 ASCO Annual Meeting

Springer Medicine

Abstract

Background

Methods

Results

Conclusion

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