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Obesity Surgery
Published in: Obesity Surgery 7/2010

01-07-2010 | Research Article

Influence of -55CT Polymorphism of UCP3 Gene on Surgical Results of Biliopancreatic Diversion

Authors: D. A. de Luis, D. Pacheco, R. Aller, M. González Sagrado, O. Izaola, M. C. Terroba, L. Cuellar, R. Conde, T. Martin, J. L. Perez Castrillon

Published in: Obesity Surgery | Issue 7/2010

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Abstract

Background

Bariatric surgery is the most effective long-term treatment for morbid obesity, reducing obesity-associated comorbidities. The purpose of the present study was to evaluate the UCP3 promotor (-55C→T) polymorphism outcomes 1 year after biliopancreatic diversion in morbidly obese patients.

Methods

A sample of 40 morbidly obese patients (BMI >40 kg/m2) were operated. Weight, fat mass, blood pressure, basal glucose, triacylglycerols, total cholesterol, low-density lipoprotein cholesterol, and high-density lipoprotein cholesterol were measured at basal visit and at each visit. The frequency of patients with diabetes mellitus, hypertension, and hyperlipidemia was recorded at each visit.

Results

Twenty-eight patients (70%) had the genotype C/C (wild group) and 12 (30%) patients C/T (mutant group). In wild type group, body mass index, weight, fat mass, systolic blood pressure, glucose, total cholesterol, low-density lipoprotein cholesterol, and triacylglycerols concentrations decreased. In mutant type group, the same parameters improved, without statistical differences with wild group. Initial weight percent loss at 1 year of follow-up was similar in both genotypes (34.1% vs 28.6%; ns).

Conclusion

Polymorphism -55C/T of the UCP3 promotor did not have an effect on weight loss or clinical outcomes after bariatric surgery.
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Metadata
Title
Influence of -55CT Polymorphism of UCP3 Gene on Surgical Results of Biliopancreatic Diversion
Authors
D. A. de Luis
D. Pacheco
R. Aller
M. González Sagrado
O. Izaola
M. C. Terroba
L. Cuellar
R. Conde
T. Martin
J. L. Perez Castrillon
Publication date
01-07-2010
Publisher
Springer-Verlag
Published in
Obesity Surgery / Issue 7/2010
Print ISSN: 0960-8923
Electronic ISSN: 1708-0428
DOI
https://doi.org/10.1007/s11695-008-9510-2

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