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Breast Cancer Research
Published in: Breast Cancer Research 4/2007

01-08-2007 | Review

Inflammation and breast cancer. Inflammatory component of mammary carcinogenesis in ErbB2 transgenic mice

Authors: Raffaele Adolfo Calogero, Francesca Cordero, Guido Forni, Federica Cavallo

Published in: Breast Cancer Research | Issue 4/2007

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Abstract

This review addresses genes differentially expressed in the mammary gland transcriptome during the progression of mammary carcinogenesis in BALB/c mice that are transgenic for the rat neu (ERBB2, or HER-2/neu) oncogene (BALB-neuT664V-E mice). The Ingenuity knowledge database was used to characterize four functional association networks whose hub genes are directly linked to inflammation (specifically, the genes encoding IL-1β, tumour necrosis factor, interferon-γ, and monocyte chemoattractant protein-1/CC chemokine ligand-2) and are increasingly expressed during such progression. In silico meta-analysis in a human breast cancer dataset suggests that proinflammatory activation in the mammary glands of these mice reflects a general pattern of human breast cancer.
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Metadata
Title
Inflammation and breast cancer. Inflammatory component of mammary carcinogenesis in ErbB2 transgenic mice
Authors
Raffaele Adolfo Calogero
Francesca Cordero
Guido Forni
Federica Cavallo
Publication date
01-08-2007
Publisher
BioMed Central
Published in
Breast Cancer Research / Issue 4/2007
Electronic ISSN: 1465-542X
DOI
https://doi.org/10.1186/bcr1745

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