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Current Obstetrics and Gynecology Reports

05-04-2024 | Infertility | REVIEW

Role of Immunological Testing in Infertility

Authors: Mary Kathryn Abel, Mackenzie N. Naert, Abigail M. Kempf, Antonio R. Gargiulo

Published in: Current Obstetrics and Gynecology Reports

Abstract

Purpose of Review

Unexplained infertility, recurrent pregnancy loss, and recurrent implantation failure are challenging clinical scenarios, both for patients and providers. The role of immunologic testing for these conditions is an area of new and expanding research. This review presents the current, existing evidence on the role of immunological testing in infertility.

Recent Findings

A number of different immunological tests for infertility are available, including antiphospholipid antibodies, antithyroid antibodies, antinuclear antibodies, endometrial studies, uterine natural killer cells, systemic natural killer cells, Th1/Th2 cells, and Th17/regulatory T cells. There has been tremendous variation in the use of these tests for infertility and recurrent pregnancy loss, likely driven by a lack of consensus on their utility.

Summary

Our review concludes that there are significant limitations to immunological testing in this setting. Larger, prospective studies are needed prior to mass adoption of many immunologic tests.

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Title: Role of Immunological Testing in Infertility
Authors: Mary Kathryn Abel
Mackenzie N. Naert
Abigail M. Kempf
Antonio R. Gargiulo
Publication date: 05-04-2024
Publisher: Springer US
Keywords: Infertility
Infertility
Miscarriage
Published in: Current Obstetrics and Gynecology Reports
Electronic ISSN: 2161-3303
DOI: https://doi.org/10.1007/s13669-024-00381-2

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Role of Immunological Testing in Infertility

Abstract

Purpose of Review

Recent Findings

Summary

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Purpose of Review

Recent Findings

Summary

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