Top

Published in:

23-03-2023 | Infertility | Review Article

Effects of mindfulness-based intervention for women with infertility: a systematic review and meta-analysis

Authors: Guangpeng Wang, Xueyan Liu, Jun Lei

Published in: Archives of Women's Mental Health | Issue 2/2023

Abstract

This review aimed to examine the effects of mindfulness-based interventions on physical and psychological outcomes in women with infertility. Studies were included if participants were women diagnosed with infertility, were over the age of 18, and the design was a randomized controlled trial of a mindfulness-based intervention program. Two independent reviewers undertook eligibility screening, data extraction, and methodological quality assessment. We used RevMan software version 5.4 (The Cochrane Collaboration) to conduct the meta-analyses. The Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) was followed. Ten articles were finally included in the current meta-analysis. The results of the meta-analysis revealed large, significant effects of mindfulness-based interventions that can effectively reduce depression[SMD = −1.28, 95% CI (−1.95, −0.60), P < 0.0001], anxiety [SMD = −0.89, 95% CI (−1.26, −0.51), P < 0.00001] symptoms, and improve five domains of health-related quality of life (physical function [MD = 9.47, 95% CI (4.33, 14.61), P = 0.0003], general health [MD = 15.77, 95% CI (7.62, 23.92), P = 0.0002], vitality [MD = 14.85, 95% CI (4.95, 24.74), P = 0.003], role-physical [MD = 22.44, 95% CI (14.97, 29.91), P < 0.00001] and social function [MD = 8.27, 95% CI (3.56, 12.97), P = 0.0006)] in women with infertility. The current meta-analysis results revealed that mindfulness-based interventions could effectively reduce depression and anxiety symptoms and improve health-related quality of life in women with infertility. Future rigorously designed, high-quality research is required to demonstrate whether mindfulness-based intervention programs can effectively reduce perceived stress and BMI.

Amarasekera AT, Chang D (2019) Buddhist meditation for vascular function: a narrative review. Integr med res 8(4):252–256. https://doi.org/10.1016/j.imr.2019.11.002CrossRefPubMedPubMedCentral

Asemota OA, Klatsky P (2015) Access to infertility care in the developing world: the family promotion gap. Semin Reprod Med 33(1):17–22. https://doi.org/10.1055/s-0034-1395274CrossRefPubMed

Ashraf DM, Ali D, Azadeh DM (2014) Effect of infertility on the quality of life, a cross- sectional study. J Clin Diagn Res 8(10):Oc13–Oc15. https://doi.org/10.7860/jcdr/2014/8481.5063CrossRefPubMed

Bai CF, Cui NX, Xu X, Mi GL, Sun JW, Shao D et al (2019) Effectiveness of two guided self-administered interventions for psychological distress among women with infertility: a three-armed, randomized controlled trial. Hum Reprod 34(7):1235–1248. https://doi.org/10.1093/humrep/dez066CrossRefPubMed

Chachamovich JR, Chachamovich E, Ezer H, Fleck MP, Knauth D, Passos EP (2010) Investigating quality of life and health-related quality of life in infertility: a systematic review. J Psychosom Obstet Gynaecol 31(2):101–110. https://doi.org/10.3109/0167482x.2010.481337CrossRefPubMed

Chamorro PP, Herruzo J, Pino MJ (2021) Study on the interdependent relationship between the marital satisfaction variable and the psychosocial impact of infertility and anxiety disposition, according to gender. J Sex Marital Ther 1–14. https://doi.org/10.1080/0092623x.2021.2008074

Chan CH, Chan CL, Ng EH, Ho PC, Chan TH, Lee GL, Hui WH (2012) Incorporating spirituality in psychosocial group intervention for women undergoing in vitro fertilization: a prospective randomized controlled study. Psychol Psychother 85(4):356–373. https://doi.org/10.1111/j.2044-8341.2011.02040.xCrossRefPubMed

Chan CHY, Ng EHY, Chan CLW, Ho PC, Chan THY (2006) Effectiveness of psychosocial group intervention for reducing anxiety in women undergoing in vitro fertilization: a randomized controlled study. Fertil Steril 85(2):339–346. https://doi.org/10.1016/j.fertnstert.2005.07.1310CrossRefPubMed

Chen Y, Yang H, Liu L, Fang R (2017) Effects of mindfulness-based stress reduction on the anxiety, depression and quality of life of patients with intrauterine adhesion: a randomized controlled trial. Inter J Clin Exp Med 10(2):2296–2305. Retrieved from <Go to ISI>://WOS:000396518500055

Cohen J (1988) Statistical power analysis for the behavioral sciences, 2nd edn. Routledge. https://doi.org/10.4324/9780203771587

Copel J (2014) Re: economic analysis of use of pessary to prevent preterm birth in women with multiple pregnancy (ProTWIN trial). S. M. S. Liem, G. J. van Baaren, F. M. C. Delemarre, I. M. Evers, G. Kleiverda, A. J. van Loon, J. Langenveld, N. Schuitemaker, J. M. Sikkema, B. C. Opmeer, M. G. van Pampus, B. W. J. Mol and D. J. Bekedam. Ultrasound Obstet Gynecol 2014; 44: 338–345. Ultrasound Obstet Gynecol 44(3):252. https://doi.org/10.1002/uog.13459

Crawford NM, Hoff HS, Mersereau JE (2017) Infertile women who screen positive for depression are less likely to initiate fertility treatments. Hum Reprod 32(3):582–587. https://doi.org/10.1093/humrep/dew351CrossRefPubMedPubMedCentral

Cserepes RE, Kőrösi T, Bugán A (2014) Characteristics of infertility-specific quality of life in Hungarian couples. Orv Hetil 155(20):783–788. https://doi.org/10.1556/oh.2014.29867CrossRefPubMed

Dadhwal V, Choudhary V, Perumal V, Bhattacharya D (2021) Depression, anxiety, quality of life and coping in women with infertility: a cross-sectional study from India. Int J Gynaecol Obstet. https://doi.org/10.1002/ijgo.14084

de Mouzon J, Goossens V, Bhattacharya S, Castilla JA, Ferraretti AP, Korsak V, Nyboe Andersen A (2010) Assisted reproductive technology in Europe, 2006: results generated from European registers by ESHRE. Hum Reprod 25(8):1851–1862. https://doi.org/10.1093/humrep/deq124CrossRefPubMed

Faramarzi M, Pasha H, Esmailzadeh S, Kheirkhah F, Heidary S, Afshar Z (2013) The effect of the cognitive behavioral therapy and pharmacotherapy on infertility stress: a randomized controlled trial. Inter J Fertil Steril 7(3):199–206

Galhardo A, Cunha M, Pinto-Gouveia J (2013) Mindfulness-based program for infertility: efficacy study. Fertil Steril 100(4):1059–1067. https://doi.org/10.1016/j.fertnstert.2013.05.036CrossRefPubMed

Gdańska P, Drozdowicz-Jastrzębska E, Grzechocińska B, Radziwon-Zaleska M, Węgrzyn P, Wielgoś M (2017) Anxiety and depression in women undergoing infertility treatment. Ginekol Pol 88(2):109–112. https://doi.org/10.5603/GP.a2017.0019CrossRefPubMed

Gungor ES, Seval O, Ilhan G, Verit FF (2018) Effect of intrauterine insemination treatment on sexual function and quality of life for infertile women. Pak J Med Sci 34(4):891–896. https://doi.org/10.12669/pjms.344.14789CrossRefPubMedPubMedCentral

Higgins JP, Altman DG, Gøtzsche PC, Jüni P, Moher D, Oxman AD, Sterne JA (2011) The Cochrane Collaboration's tool for assessing risk of bias in randomised trials. BMJ 343:d5928. https://doi.org/10.1136/bmj.d5928CrossRefPubMedPubMedCentral

Hofmann SG, Gómez AF (2017) Mindfulness-based interventions for anxiety and depression. Psychiatr Clin North Am 40(4):739–749. https://doi.org/10.1016/j.psc.2017.08.008CrossRefPubMedPubMedCentral

Hosaka T, Matsubayashi H, Sugiyama Y, Izumi S, Makino T (2002) Effect of psychiatric group intervention on natural-killer cell activity and pregnancy rate. Gen Hosp Psychiatry 24(5):353–356. https://doi.org/10.1016/s0163-8343(02)00194-9CrossRefPubMed

Hosseini MS, Mousavi P, Hekmat K, Haghighyzadeh MH, Fard RJ, Jafari RM (2020) Effects of a short-term mindfulness-based stress reduction program on the quality of life of women with infertility: a randomized controlled clinical trial. Complement Ther Med 50. https://doi.org/10.1016/j.ctim.2020.102403

Howard S (2018) The hidden costs of infertility treatment. BMJ 361:k2204. https://doi.org/10.1136/bmj.k2204CrossRefPubMed

Ingebretsen M (2009) Wherever you go, there you are. IEEE Intell Syst 24(6):92

Kalhori F, Masoumi SZ, Shamsaei F, Mohammadi Y, Yavangi M (2020a) Effect of mindfulness-based group counseling on depression in infertile women: randomized clinical trial study. Inter JFertil Steril 14(1):10–16. https://doi.org/10.22074/ijfs.2020.5785

Kalhori F, Seyedeh Zahra M, Shamsaei F, Mohammadi Y, Yavangi M (2020b) Effect of mindfulness-based group counseling on depression in infertile women: clinical trial study. Inter J Fertil Steril 14(1):10–16. https://doi.org/10.22074/ijfs.2020.5785

Keng SL, Smoski MJ, Robins CJ (2011) Effects of mindfulness on psychological health: a review of empirical studies. Clin Psychol Rev 31(6):1041–1056. https://doi.org/10.1016/j.cpr.2011.04.006CrossRefPubMedPubMedCentral

Kiani Z, Simbar M, Hajian S, Zayeri F (2021) The prevalence of depression symptoms among infertile women: a systematic review and meta-analysis. Fertil Res Pract 7(1):6. https://doi.org/10.1186/s40738-021-00098-3CrossRefPubMedPubMedCentral

Kiani Z, Simbar M, Hajian S, Zayeri F, Shahidi M, Naz SG, M, Ghasemi V (2020) The prevalence of anxiety symptoms in infertile women: a systematic review and meta-analysis. Fertil Res Pract 6:7. https://doi.org/10.1186/s40738-020-00076-1

Lakatos E, Szigeti JF, Ujma PP, Sexty R, Balog P (2017) Anxiety and depression among infertile women: a cross-sectional survey from Hungary. BMC Womens Health 17(1):48. https://doi.org/10.1186/s12905-017-0410-2CrossRefPubMedPubMedCentral

Majeed MH, Ali AA, Sudak DM (2018) Mindfulness-based interventions for chronic pain: evidence and applications. Asian J Psychiatr 32:79–83. https://doi.org/10.1016/j.ajp.2017.11.025CrossRefPubMed

Martinez G, Daniels K, Chandra A (2012) Fertility of men and women aged 15-44 years in the United States: National Survey of Family Growth, 2006-2010. Natl Health Stat Report (51):1–28

Mascarenhas MN, Flaxman SR, Boerma T, Vanderpoel S, Stevens GA (2012) National, regional, and global trends in infertility prevalence since 1990: a systematic analysis of 277 health surveys. PLoS Med 9(12):e1001356. https://doi.org/10.1371/journal.pmed.1001356CrossRefPubMedPubMedCentral

Massarotti C, Gentile G, Ferreccio C, Scaruffi P, Remorgida V, Anserini P (2019) Impact of infertility and infertility treatments on quality of life and levels of anxiety and depression in women undergoing in vitro fertilization. Gynecol Endocrinol 35(6):485–489. https://doi.org/10.1080/09513590.2018.1540575CrossRefPubMed

Mousavi E, Hosseini S, Bakhtiyari M, Abasi I, Mohammadi A, Masjedi Arani A (2020) The effects of mindfulness-based stress reduction group therapy on anxiety, depression, stress, and the intolerance of uncertainty in infertile women. Iran J Rehab Res 18(2):137–144. Retrieved from https://ovidsp.ovid.com/athens?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=psyc18&AN=2021-40398-004

Mousavi E, Hosseini S, Bakhtiyari M, Mohammadi A, Isfeedvajani MS, Arani AM, Sadaat SH (2019) Comparing the effectiveness of the unified protocol transdiagnostic and mindfulness-based stress reduction program on anxiety and depression in infertile women receiving in vitro fertilisation. JResMed Dent Sci 7(2):44–51. Retrieved from <Go to ISI>://WOS:000469250600008

Namavar Jahromi B, Mansouri M, Forouhari S, Poordast T, Salehi A (2018) Quality of life and its influencing factors of couples referred to an infertility center in Shiraz. Iran Int J Fertil Steril 11(4):293–297. https://doi.org/10.22074/ijfs.2018.5123CrossRefPubMed

Polis CB, Cox CM, Tunçalp Ö, McLain AC, Thoma ME (2017) Estimating infertility prevalence in low-to-middle-income countries: an application of a current duration approach to Demographic and Health Survey data. Hum Reprod 32(5):1064–1074. https://doi.org/10.1093/humrep/dex025CrossRefPubMedPubMedCentral

Rahiminejad ME, Moaddab A, Ebrahimi M, Rabiee S, Zamani A, Ezzati M, Abdollah Shamshirsaz A (2015) The relationship between some endometrial secretion cytokines and in vitro fertilization. Iran J Reprod Med 13(9):557–562PubMedPubMedCentral

Rich CW, Domar AD (2016) Addressing the emotional barriers to access to reproductive care. Fertil Steril 105(5):1124–1127. https://doi.org/10.1016/j.fertnstert.2016.02.017CrossRefPubMed

Royani Z, Heidari M, Vatanparast M, Yaghmaei F, Sarcheshme AK, Majomerd JK (2019) Predictors of quality of life in infertile couples. J Menopausal Med 25(1):35–40. https://doi.org/10.6118/jmm.2019.25.1.35CrossRefPubMedPubMedCentral

Safarinejad MR (2008) Infertility among couples in a population-based study in Iran: prevalence and associated risk factors. Int J Androl 31(3):303–314. https://doi.org/10.1111/j.1365-2605.2007.00764.xCrossRefPubMed

Sant'Anna EM, Paiva SPC, Santos RP, Rodrigues AMS, Davis NA, Nery SF, Maia FP, Ferreira AVM, Reis FM (2022) Mindfulness-based program to support lifestyle modification and weight loss in infertile women: randomized controlled trial. J Psychosom Obstet Gynaecol 43(2):136–144. https://doi.org/10.1080/0167482x.2020.1823962

Shani C, Yelena S, Reut BK, Adrian S, Sami H (2016) Suicidal risk among infertile women undergoing in-vitro fertilization: Incidence and risk factors. Psychiatry Res 240:53–59. https://doi.org/10.1016/j.psychres.2016.04.003CrossRefPubMed

Starc A, Trampuš M, Pavan Jukić D, Rotim C, Jukić T, Polona Mivšek A (2019) Infertility and sexual dysfunctions: a systematic literature review. Acta Clin Croat 58(3):508–515. https://doi.org/10.20471/acc.2019.58.03.15CrossRefPubMedPubMedCentral

Stefanaki C, Bacopoulou F, Livadas S, Kandaraki A, Karachalios A, Chrousos GP, Diamanti-Kandarakis E (2015) Impact of a mindfulness stress management program on stress, anxiety, depression and quality of life in women with polycystic ovary syndrome: a randomized controlled trial. Stress: The International Journal on the Biology of Stress 18(1):57–66. Retrieved from https://ovidsp.ovid.com/athens?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=psyc12&AN=2015-09182-008CrossRefPubMed

Vander Borght M, Wyns C (2018) Fertility and infertility: definition and epidemiology. Clin Biochem 62:2–10. https://doi.org/10.1016/j.clinbiochem.2018.03.012CrossRefPubMed

Zegers-Hochschild F, Adamson GD, de Mouzon J, Ishihara O, Mansour R, Nygren K, Vanderpoel S (2009) International Committee for Monitoring Assisted Reproductive Technology (ICMART) and the World Health Organization (WHO) revised glossary of ART terminology, 2009. Fertil Steril 92(5):1520–1524. https://doi.org/10.1016/j.fertnstert.2009.09.009CrossRefPubMed

Title: Effects of mindfulness-based intervention for women with infertility: a systematic review and meta-analysis
Authors: Guangpeng Wang
Xueyan Liu
Jun Lei
Publication date: 23-03-2023
Publisher: Springer Vienna
Keywords: Infertility
Mood Disorders
Infertility
Affective Disorder
Anxiety
Published in: Archives of Women's Mental Health / Issue 2/2023
Print ISSN: 1434-1816
Electronic ISSN: 1435-1102
DOI: https://doi.org/10.1007/s00737-023-01307-2

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Effects of mindfulness-based intervention for women with infertility: a systematic review and meta-analysis

Abstract

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Please log in to get access to this content

Other articles of this Issue 2/2023

Job satisfaction and well-being among college-educated Bedouin Arab and ultra-Orthodox women in the Israeli workforce: the roles of individual, familial, communal, and organizational resources

Correction to: Diversity in high‑impact psychiatric publishing: gender parity within reach?

The microbiota-gut-brain axis and perceived stress in the perinatal period

Risk for trauma-related distress following difficult childbirth: Trajectories of traumatic intrusions across 2 years postpartum

Associations of premenstrual symptoms with daily rumination and perceived stress and the moderating effects of mindfulness facets on symptom cyclicity in premenstrual syndrome

The importance of high-quality partner support for reducing stress during pregnancy and postpartum bonding impairments