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Open Access 01-04-2010 | Research

Infections of respiratory or abdominal origin in ICU patients: what are the differences?

Authors: Elena Volakli, Claudia Spies, Argyris Michalopoulos, AB Johan Groeneveld, Yasser Sakr, Jean-Louis Vincent

Published in: Critical Care | Issue 2/2010

Abstract

Introduction

There are few data related to the effects of different sources of infection on outcome. We used the Sepsis Occurrence in Acutely ill Patients (SOAP) database to investigate differences in the impact of respiratory tract and abdominal sites of infection on organ failure and survival.

Methods

The SOAP study was a cohort, multicenter, observational study which included data from all adult patients admitted to one of 198 participating intensive care units (ICUs) from 24 European countries during the study period. In this substudy, patients were divided into two groups depending on whether, on admission, they had abdominal infection but no respiratory infection or respiratory infection but no abdominal infection. The two groups were compared with respect to patient and infection-related characteristics, organ failure patterns, and outcomes.

Results

Of the 3,147 patients in the SOAP database, 777 (25%) patients had sepsis on ICU admission; 162 (21%) had abdominal infection without concurrent respiratory infection and 380 (49%) had respiratory infection without concurrent abdominal infection. Age, sex, and severity scores were similar in the two groups. On admission, septic shock was more common in patients with abdominal infection (40.1% vs. 29.5%, P = 0.016) who were also more likely to have early coagulation failure (17.3% vs. 9.5%, P = 0.01) and acute renal failure (38.3% vs. 29.5%, P = 0.045). In contrast, patients with respiratory infection were more likely to have early neurological failure (30.5% vs. 9.9%, P < 0.001). The median length of ICU stay was the same in the two groups, but the median length of hospital stay was longer in patients with abdominal than in those with respiratory infection (27 vs. 20 days, P = 0.02). ICU (29%) and hospital (38%) mortality rates were identical in the two groups.

Conclusions

There are important differences in patient profiles related to the site of infection; however, mortality rates in these two groups of patients are identical.

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Title: Infections of respiratory or abdominal origin in ICU patients: what are the differences?
Authors: Elena Volakli
Claudia Spies
Argyris Michalopoulos
AB Johan Groeneveld
Yasser Sakr
Jean-Louis Vincent
Publication date: 01-04-2010
Publisher: BioMed Central
Published in: Critical Care / Issue 2/2010
Electronic ISSN: 1364-8535
DOI: https://doi.org/10.1186/cc8909

2024 ASCO Annual Meeting

Springer Medicine

Infections of respiratory or abdominal origin in ICU patients: what are the differences?

Abstract

Introduction

Methods

Results

Conclusions

2024 ASCO Annual Meeting

Springer Medicine

Abstract

Introduction

Methods

Results

Conclusions

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