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BMC Complementary Medicine and Therapies

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Open Access 01-12-2015 | Research article

Induction of substantial myocardial regeneration by an active fraction of the Chinese herb Rosa laevigata Michx

Authors: Huiyan Qu, Zhou Feng, Zhongyu Li, Censing Li, Mingfeng Tang, Zhen Zhou, Dianbin Li, Yongming Liu, Ming Li, Hua Zhou

Published in: BMC Complementary Medicine and Therapies | Issue 1/2015

Abstract

Background

The replacement of lost cardiac tissues by regenerated myocardium would be a therapeutic ideal for myocardial infarction. The objective of this study was therefore to evaluate the ability of an active fraction that was isolated from Rosa laevigata Michx in therapeutic cardiomyogenesis in a myocardial infarction rat model.

Methods

The myocardial infarction animal model was induced by the permanent ligation of the left anterior descending coronary artery in rats. The active fraction, which improves the survival rate and prevents ischemic reperfusion damage, was used to test the therapeutic effect of this fraction on myocardial infarction.

Results

The oral administration of the active fraction for 4 weeks could progressively restore the decreased cardiac function due to myocardial infarction. The significantly improved cardiac function was probably attributed to the active fraction-induced myocardial regeneration, which replaced the lost cardiac tissues in the myocardial infarction animals.

Conclusions

The property of this active fraction appears to be entirely novel and may provide a potential therapeutic alternative for myocardial infarction.

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Title: Induction of substantial myocardial regeneration by an active fraction of the Chinese herb Rosa laevigata Michx
Authors: Huiyan Qu
Zhou Feng
Zhongyu Li
Censing Li
Mingfeng Tang
Zhen Zhou
Dianbin Li
Yongming Liu
Ming Li
Hua Zhou
Publication date: 01-12-2015
Publisher: BioMed Central
Published in: BMC Complementary Medicine and Therapies / Issue 1/2015
Electronic ISSN: 2662-7671
DOI: https://doi.org/10.1186/s12906-015-0795-0

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Induction of substantial myocardial regeneration by an active fraction of the Chinese herb Rosa laevigata Michx

Abstract

Background

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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