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Virology Journal
Published in: Virology Journal 1/2013

Open Access 01-12-2013 | Research

Induction of cytopathic effect and cytokines in coxsackievirus B3-infected murine astrocytes

Authors: Jun Zeng, Gefei Wang, Weizhong Li, Dangui Zhang, Xiaoxuan Chen, Gang Xin, Zhiwu Jiang, Kangsheng Li

Published in: Virology Journal | Issue 1/2013

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Abstract

Background

Coxsackievirus commonly infects children and occasionally causes severe meningitis and/or encephalitis in the newborn. The underlying mechanism(s) behind the central nervous system pathology is poorly defined.

Methods

It is hypothesized that astrocytes may be involved in inflammatory response induced by CVB3 infection. Here we discuss this hypothesis in the context of CVB3 infection and associated inflammatory response in primary mouse astrocytes.

Results

The results showed that coxsackievirus receptor (CAR) was distributed homogeneously on the astrocytes, and that CVB3 could infect and replicate in astrocytes, with release of infectious virus particles. CVB3 induced cytopathic effect and production of proinflammatory cytokines IL-1β, TNF-α, IL-6, and chemokine CXCL10 from astrocytes.

Conclusion

These data suggest that direct astrocyte damage and cytokines induction could be a mechanism of virus-induced meningitis and/or encephalitis.
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Metadata
Title
Induction of cytopathic effect and cytokines in coxsackievirus B3-infected murine astrocytes
Authors
Jun Zeng
Gefei Wang
Weizhong Li
Dangui Zhang
Xiaoxuan Chen
Gang Xin
Zhiwu Jiang
Kangsheng Li
Publication date
01-12-2013
Publisher
BioMed Central
Published in
Virology Journal / Issue 1/2013
Electronic ISSN: 1743-422X
DOI
https://doi.org/10.1186/1743-422X-10-157

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