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Environmental Health and Preventive Medicine

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01-05-2014 | Short Communication

Induction of activation-induced cytidine deaminase by a not-directly mutagenic carcinogen: a novel potential molecular mechanism

Authors: Masayuki Tatemichi, Harumi Hata, Toshio Nakadate

Published in: Environmental Health and Preventive Medicine | Issue 3/2014

Abstract

Objective

The molecular mechanisms underlying the carcinogenic activity of not-directly mutagenic (Ames mutagenicity test-negative) carcinogens are not fully understood. Given recent findings that ectopic expression of activation-induced cytidine deaminase (AID) in somatic cells plays a critical role in carcinogenesis, we investigated whether several of the established not-directly mutagenic carcinogens induce AID expression.

Methods

We prepared cells with stable expression of luciferase reporter gene containing the promoter of AID. We then used this system to examine the AID promoter activity of the non-genotoxic carcinogen: butyl benzyl phthalate, bisphenol A, di (2-ethylhexyl) phthalate, cadmium chloride (Cd), and butylated hydroxyanisole.

Results

Results showed that Cd increased the promoter activity of AID and actually induced AID gene expression.

Conclusion

A not-directly mutagenic carcinogen, cadmium, has the potential to induce the AID gene, suggesting that this might represent a novel molecular mechanism of carcinogenesis of cadmium.

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Title: Induction of activation-induced cytidine deaminase by a not-directly mutagenic carcinogen: a novel potential molecular mechanism
Authors: Masayuki Tatemichi
Harumi Hata
Toshio Nakadate
Publication date: 01-05-2014
Publisher: Springer Japan
Published in: Environmental Health and Preventive Medicine / Issue 3/2014
Print ISSN: 1342-078X
Electronic ISSN: 1347-4715
DOI: https://doi.org/10.1007/s12199-014-0382-x

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Induction of activation-induced cytidine deaminase by a not-directly mutagenic carcinogen: a novel potential molecular mechanism

Abstract

Objective

Methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Objective

Methods

Results

Conclusion

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