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01-10-2008 | Review Article

Induced pluripotent stem (iPS) cells as in vitro models of human neurogenetic disorders

Authors: Stormy J. Chamberlain, Xue-Jun Li, Marc Lalande

Published in: Neurogenetics | Issue 4/2008

Abstract

The recent discovery of genomic reprogramming of human somatic cells into induced pluripotent stem cells offers an innovative and relevant approach to the study of human genetic and neurogenetic diseases. By reprogramming somatic cells from patient samples, cell lines can be isolated that self-renew indefinitely and have the potential to develop into multiple different tissue lineages. Additionally, the rapid progress of research on human embryonic stem cells has led to the development of sophisticated in vitro differentiation protocols that closely mimic mammalian development. In particular, there have been significant advances in differentiating human pluripotent stem cells into defined neuronal types. Here, we summarize the experimental approaches employed in the rapidly evolving area of somatic cell reprogramming and the methodologies for differentiating human pluripotent cells into neurons. We also discuss how the availability of patient-specific fibroblasts offers a unique opportunity for studying and modeling the effects of specific gene defects on human neuronal development in vitro and for testing small molecules or other potential therapies for the relevant neurogenetic disorders.

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Title: Induced pluripotent stem (iPS) cells as in vitro models of human neurogenetic disorders
Authors: Stormy J. Chamberlain
Xue-Jun Li
Marc Lalande
Publication date: 01-10-2008
Publisher: Springer-Verlag
Published in: Neurogenetics / Issue 4/2008
Print ISSN: 1364-6745
Electronic ISSN: 1364-6753
DOI: https://doi.org/10.1007/s10048-008-0147-z

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Springer Medicine

Induced pluripotent stem (iPS) cells as in vitro models of human neurogenetic disorders

Abstract

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

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