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Breast Cancer Research
Published in: Breast Cancer Research 1/2014

Open Access 01-02-2014 | Letter

Individual xenograft as a personalized therapeutic resort for women with metastatic triple-negative breast carcinoma

Authors: Guilhem Bousquet, Jean-Paul Feugeas, Irmine Ferreira, Laetitia Vercellino, Nathalie Jourdan, Philippe Bertheau, Cédric de Bazelaire, Emmanuel Barranger, Anne Janin

Published in: Breast Cancer Research | Issue 1/2014

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Excerpt

A localized left breast ductal invasive triple-negative breast carcinoma (TNBC) was diagnosed in a 44-year-old woman. After surgery, she was treated with chemotherapy and radiation therapy in accordance with national guidelines. At the end of treatment, she had local and metastatic relapse with multiple sub-diaphragmatic lymph nodes. …
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Literature
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Lehmann BD, Bauer JA, Chen X, Sanders ME, Chakravarthy AB, Shyr Y, Pietenpol JA: Identification of human triple-negative breast cancer subtypes and preclinical models for selection of targeted therapies. J Clin Invest. 2011, 121: 2750-2767. 10.1172/JCI45014.CrossRefPubMedPubMedCentral
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Masuda H, Baggerly KA, Wang Y, Zhang Y, Gonzalez-Angulo AM, Meric-Bernstam F, Valero V, Lehmann BD, Pietenpol JA, Hortobagyi GN, Symmans WF, Ueno NT: Differential response to neoadjuvant chemotherapy among 7 triple-negative breast cancer molecular subtypes. Clin Cancer Res. 2013, 19: 5533-5540. 10.1158/1078-0432.CCR-13-0799.CrossRefPubMed
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Gerlinger M, Rowan AJ, Horswell S, Larkin J, Endesfelder D, Gronroos E, Martinez P, Matthews N, Stewart A, Tarpey P, Varela I, Phillimore B, Begum S, McDonald NQ, Butler A, Jones D, Raine K, Latimer C, Santos CR, Nohadani M, Eklund AC, Spencer-Dene B, Clark G, Pickering L, Stamp G, Gore M, Szallasi Z, Downward J, Futreal PA, Swanton C: Intratumor heterogeneity and branched evolution revealed by multiregion sequencing. N Engl J Med. 2012, 366: 883-892. 10.1056/NEJMoa1113205.CrossRefPubMedPubMedCentral
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Metadata
Title
Individual xenograft as a personalized therapeutic resort for women with metastatic triple-negative breast carcinoma
Authors
Guilhem Bousquet
Jean-Paul Feugeas
Irmine Ferreira
Laetitia Vercellino
Nathalie Jourdan
Philippe Bertheau
Cédric de Bazelaire
Emmanuel Barranger
Anne Janin
Publication date
01-02-2014
Publisher
BioMed Central
Published in
Breast Cancer Research / Issue 1/2014
Electronic ISSN: 1465-542X
DOI
https://doi.org/10.1186/bcr3615

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